BACKGROUND MET gene amplification and Met protein overexpression may be associated with a poor prognosis. The MET/Met status is typically determined with fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC), respectively. Targeted proteomics uses mass spectrometry-based selected reaction monitoring (SRM) to accurately quantitate Met expression. FISH, IHC, and SRM analyses we...

Selected reaction monitoring (SRM), also called multiple reaction monitoring, has become an invaluable tool for targeted quantitative proteomic analyses, but its application can be compromised by nonoptimal selection of transitions. In particular, complex backgrounds may cause ambiguities in SRM measurement results because peptides with interfering transitions similar to those of the target pep...

Today, switched reluctance motors (SRMs) represent a promising technology for the long-term sustainability of electrified transportation, mainly due to their simpler structure, lower production cost, and robust configuration compared other motor technologies. Notwithstanding, high acoustic noise torque ripple are two performance imperfections that have prevented widespread implementation SRMs. ...

The incompressibility constraint makes Navier-Stokes equations difficult. A reformulation to a better posed problem is needed before solving it numerically. The sequential regularization method (SRM) is a reformulation which combines the penalty method with a stabilization method in the context of constrained dynamical systems and has the benefit of both methods. In the paper, we study the exis...

BACKGROUND AND OBJECTIVES Illness representations in physical health problems have been studied extensively using the Self-regulation Model (SRM) focusing on five dimensions of illness beliefs (identity, consequences, causes, timeline and control, or cure). Associations have been found between beliefs about illness and a range of health outcomes. This study aimed to examine models of depression...

The Caribbean, along with other small island developing states (SIDS), have advocated for restricting global warming to 1.5 °C above pre-industrial levels by the end of current century. Solar radiation management (SRM) may be one way achieve this goal. This paper examines mean Caribbean climate under various scenarios an SRM-altered versus SRM-unaltered world three targets, namely, 1.5, 2.0 and...

Ibis paper investigates the application of fuzzy algorithm for the speed control of switched reluctance motor (SRM) drives. For the purpose of performance simulation of closed loop SRM drive, its components are modelled in a systematic manner. Hysteresis current controlled midpoint converter is employed to feed four phase 8/6 SRM. Non-linearity caused by magnetic saturation in the motor is also...

In this paper, we propose a new non-homogeneous Poisson process (NHPP) based software reliability model (SRM), where the debug rate is given by local polynomial function. The main feature of semi-parametric SRM to control goodness-of-fit changing degree. Numerical examples with 16 actual development project data are devoted comparing our well-known existing NHPP-based SRMs in terms and predicti...

Systematic Review methodology (SRm) is an increasingly popular choice for literature reviews in the Social Sciences. Although, compared to traditional narrative reviews SRm appears timeconsuming and laborious, transparency and replicability of the methodology is argued to facilitate greater clarity of review. Nevertheless, researchers in Industrial, Work and Organizational (IWO) Psychology have...