background: tumor markers are substances, which quantitatively changes in serum, during the tumor development, one such tumor marker is serum β2-microglobulin (β2-m). the aim of this study was to establish the role of β2-m as a biochemical parameter for diagnosis and prognosis of oral carcinoma by estimation of serum β2-m levels in potentially malignant lesions, conditions, and oral squamous ce...

introduction: granular cell tumors (gcts) are rare and mostly benign soft tissue tumors. though they have been reported in all parts of body, they are generally located in the head and neck region, especially on the tongue. some malign forms exist, but these have been rarely reported. granular cell tumors have a neural origin and, in immunohistochemical evaluations, they express s-100 and neuro...

: Pseudoangiosarcomatous squamous cell carcinoma, also called pseudovascular, pseudoangiomatoid or adenoid pseudovascular is an uncommon and highly aggressive variant of carcinoma. Histologically, it characterized by proliferation atypical keratinocytes with acantholysis formation spaces, forming anastomosed channels lined neoplastic cells that invade the dermis. These are positive for cytokera...

Cyclin B1-CDK1 complex plays an important role in the regulation of cell cycle. Activation of Cyclin B1 and CDK1 and the formation of the complex in G2/M are under multiple regulations involving many regulators such as isoforms of 14-3-3 and CDC25 and Wee1. Abnormal expression of Cyclin B1 and CDK1 has been detected in various tumors. However, to our knowledge no previous study has investigated...

Primary vulva malignancy is a rare gynecologic malignancy. Most of them are squamous cell carcinomas and adenocarcinomas are much less common. Intestinal type is a rare variant of primary adenocarcinoma of the vulva. It histologically resembles mucinous colonic carcinomas. Origin from cloacal remnants has been suggested but remains speculative. A 64-year-old woman was referred to our clinic wit...

THE PATIENT was a 77-year-old female who initially underwent radical vulvectomy with bilateral inguinal lymphadenectomy for classification of the International Federation of Gynaecologists and Obstetricians stage III squamous cell carcinoma of the vulva. At the time of the original treatment, there was no evidence of systemic spread of disease. Over the following 6 months, the patient developed...

AIM To study the differentiation of epithelial tissues within their histological context, and to identify hypothetically, on the basis of keratin pattern, the putative tissue origin of a (metastatic) carcinoma. METHODS Using well characterised monoclonal antibodies against individual keratins 7, 8, 18, and 19, which are predominantly found in columnar epithelia, and keratins 4, 10, 13, and 14...

Background & Objective: Chronic non healing ulcers or scar undergoing malignant transformation is a rare phenomenon with an estimated incidence of 2%. Though, numerous predisposing factors have been identified, still it is rarely diagnosed and commonly mistaken for a benign condition. The objective of this study was to verify the efficacy of the Fine Needle Aspiration Cytology/ Scrape cytology ...