The objective of the present study was to prepare and characterize in vitro and in vivo performance of a sustained release microsphere formulation of 4-chlorocurcumin, a novel curcumin analogue. A spray dried technique with ethylcellulose as the polymer was used in the preparation of these microspheres. Microspheres were characterized for drug content, particle size and shape, in vitro drug rel...

BACKGROUND Nanoemulsions consist of very stable nanodroplets of oil dispersed in an aqueous phase, typically below 300 nm in size. They can be used to obtain a very fine, homogeneous dispersion of lipophilic compounds in water, thus facilitating their handling and use in nanomedicine. However, the drawback is that they are suspended in an aqueous media. This study proposes a novel technique for...

Previous research showed that nursery pigs fed deoxynivalenol (DON) contaminated diets supplemented with spray-dried porcine plasma (SDPP) had similar growth rate and feed intake as those consuming noncontaminated diets. In this study, two blocks of 100 weanling pigs were used to determine the optimal inclusion level of spray-dried bovine plasma(SDBP) required in nursery diets contaminated with...

This work describes the development of spray dried polymer coated liposomes composed of soy phosphatidylcholine (SPC) and phospholipid dimyristoyl phosphatidylglycerol (DMPG) coated with alginate, chitosan or trimethyl chitosan (TMC), that are able to penetrate through the nasal mucosa and offer enhanced penetration over uncoated liposomes when delivered as a dry powder. All the liposome formul...

aflatoxin m1 (afm1) is an important mycotoxin frequently found in milk and dairy products. dairy products and colostrum may be contaminated by aflatoxin m1 when dairy cattle have fed with aflatoxin b1-contaminated feeds. this study was undertaken in a dairy farm around tehran province to determine the presence and level of aflatoxin m1 (afm1) in spray dried and lyophilized colostrum samples. in...

Spray dried orange flavour encapsulated in different amorphous matrices comprised of maltodextrin (MD) and different combinations with; sucrose, trehalose, lactose, modified starch and gum arabic (ga); were evaluated by sensory analysis and electronic nose (e-nose). With both techniques the flavours encapsulated in MDsucrose and MD -lactose-sucrose were perceived as similar. However, the e-nose...

The purpose of these studies was to investigate the ability of surface energy measurements and rates of mixing in dry powder inhaler (DPI) formulations to predict aerosol dispersion performance. Two lactose carrier systems comprising either spray-dried or milled particles were developed such that they had identical physical characteristics except for surface morphology and surface energies avoi...

The aim of this study was to develop a user-friendly model for spray drying that can aid in the development of a pharmaceutical product, by shifting from a trial-and-error towards a quality-by-design approach. To achieve this, a spray dryer model was developed in commercial and open source spreadsheet software. The output of the model was first fitted to the experimental output of a Büchi B-290...

Antibiotics improve health and productive performance of pigs. There is increasing evidence that other dietary ingredients may provide similar, but probably not identical, benefits. A properly prepared immune egg product, spray-dried plasma, or a high level of dietary zinc can provide protection against enteric infection in young pigs. Spray-dried plasma also increases growth rate dramatically,...

The objective of this study was to analyze the use of Spray Drying for concentration and preservation of biosurfactants produced by Bacillus subtilis LBBMA RI4914 isolated from a heavy oil reservoir. Kaolinite and maltodextrin 10DE or 20DE were tested as drying adjuvants. Surface activity of the biosurfactant was analyzed by preparing dilution x surface activity curves of crude biosurfactant, c...