BACKGROUND Parkinson's disease is a genetically complex disease with mixed mode of inheritance. Recently, a haplotype across the sepiapterin reductase (SPR) gene, which is located in the PARK3 linkage region, was shown to modulate age of onset of Parkinson's disease in sibships from North America. OBJECTIVE To make a thorough assessment of the SPR gene region in sporadic Parkinson's disease. ...

STUDY DESIGN Retrospective matched cohort study. OBJECTIVE To compare results of posterior correction and fusion with a hybrid construct using a standard posterior release (SPR) versus adding a wide posterior release (WPR), in adolescent idiopathic scoliosis (AIS) treated at a single institution, with a minimum 2-year follow-up. SUMMARY OF BACKGROUND DATA Although the importance of posterio...

We demonstrate a novel, low-cost method of building a surface plasmon resonance and fluorescence (SPRF) microscope with high quality SPR and evanescent-field fluorescence imaging using a laser pointer and an oscillating scatterer. SPR Microscopy and SPR fluorescence provide two detection modalities in a highly compact inexpensive package. Applications include point-of-care diagnostics with sens...

The techniques of surface plasmon resonance-phase imaging (SPR-PI) and nanoparticle-enhanced SPR-PI have been implemented for the multiplexed bioaffinity detection of proteins and nucleic acids. The SPR-PI experiments utilized a near-infrared 860 nm light emitting diode (LED) light source and a wedge depolarizer to create a phase grating on a four-element single-stranded DNA (ssDNA) microarray;...

Effect of Fe3O4 magnetic nanoparticle concentration on the signal of surface plasmon resonance (SPR) spectra has been successfully observed. The Fe3O4 nanoparticles with a particle size of about 10.5 ± 0.2 nm were used as active materials to increase the SPR response. X-ray diffraction (XRD) pattern showed that Fe3O4 nanoparticles have a high degree of crystallinity with spinel structure. The S...

BACKGROUND Addition of spironolactone (SPR) to angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) might provide antiproteinuric effects beyond what is gained by either medication alone. This study was designed to assess the long-term efficacy of SPR/ARB combination in comparison with the standard ACE/ARB regimen in diabetic nephropathy. METHODS In an ope...

In the present study, a surface plasmon resonance (SPR) based fiber optic sensor is proposed. The extreme sensitivity of SPR modes on the surrounding refractive index has been exploited to make the sensor. The optical fiber is coated with gold film which supports the propagation of surface plasmons. The SPR dip in the transmission spectrum is observed and its shift with varying refractive indic...

We present an numerical investigation of a planar waveguide surface plasmon resonance (SPR) sensor in silicon-oninsulator (SOI) for detecting a change in the imaginary part of the refractive index. By adding a thin adsorbed layer between the metal-analyte boundary it is found that an enhanced sensitivity of the sensor is obtained, suggesting the possibility of realizing a highly integrated and ...

In this paper, formal verification methodologies and the SPR (Safety Problem Resolver) model checking tool are used for verifying a security model’s safety. The SPR tool makes it possible to analyze security issues on security systems based on the access control model. To illustrate this approach, a case study of the Simple Access Control Model (SACM) is used and specific safety problems of the...