OBJECTIVES Keratocystic odontogenic tumors (KCOTs) are benign cystic lesions of the jaws that occur sporadically in isolation or in association with nevoid basal cell carcinoma syndrome (NBCCS). The protein patched homolog 1 gene (PTCH1) is associated with NBCCS development and tumor genesis associated with this syndrome. However, previous studies have revealed that more than 85% of syndromic K...

BACKGROUND Medullary thyroid carcinoma (MTC) may occur either as sporadic or as hereditary. Even though the sporadic form corresponds to the majority of cases, the pathogenesis is still unclear. Several polymorphisms of the ret proto-oncogene, including those located in exon 11, 13, 14 and 15 have been described in the general population and some of them seem to be over-represented in sporadic ...

We describe the current state of progress on the maximal subgroup problem for the Monster sporadic simple group. Any unknown maximal subgroup is an almost simple group whose socle is in one of 19 specified isomorphism classes.

MeduIIary thyroid carcinoma (MTC) occurs both sporadically and in the autosomal dominantly inherited multiple endocrine neoplasia (MEN) type 2 syndromes. The distinction between true sporadic MTC and a new mutation familial case is important for future clinical management of both the patient and family. The susceptibility gene for hereditary MTC is the RET proto-oncogene. DNA analysis for g...

This dissertation describes an algorithm for constructing the basic algebra Morita equivalent to the principal block of certain group algebras. This algorithm uses the method of condensation as it is described in [Lux97]. Using an intermediate condensation subalgebra allows for the construction of the projective indecomposable modules required to realize the basic algebra. The group algebras we...

In this article we give an self contained existence proof for J. Conway’s sporadic simple group Co1 [4] using the second author’s algorithm [14] constructing finite simple groups from irreducible subgroups of GLn(2). Here n = 11 and the irreducible subgroup is the Mathieu group M24. From the split extension E of M24 by a uniquely determined 11-dimensional GF(2)M24module V we construct the centr...

BACKGROUND The relative contribution of mutations in the presenilin (PSEN) and amyloid precursor protein genes to autosomal dominant and other early-onset Alzheimer disease (AD) cases is not well established. OBJECTIVES To clarify the respective contribution of the amyloid precursor protein and PSEN mutations to autosomal dominant AD and to determine its contribution to sporadic and familial ...

We say that a group is anti-solvable if all of its composition factors are non-abelian. consider particular family finite groups containing the simple alternating for n≠6 and 26 sporadic groups. prove that, K perfect field X homogeneous space smooth algebraic K-group G with geometric stabilizers lying in this family, then dominated by G-torsor. In particular, G=SL n , such spaces have rational ...

OF THE opportunistic infections reported in renal transplant patients, tuberculosis has been infrequently encountered, although its incidence is higher in this group than in the general population. I3 In our own program, sporadic cases have occurred at the rate of one or two per year. Beginning in October 1990, however, an epidemic of seven cases of tuberculosis was seen with one additional spo...