Background/Aim. Antiphospholipid syndrome (APS) is an autoimmune disorder clinically characterized by arterial or venous thrombosis and/or specific obstetric complications and presence of antiphospholipid antibodies (aPL) in the serum. It occurs in 0.3% of pregnant women, while 1% of them have two spontaneous abortions. The aim of this study was to analyze the frequency of biphospholipid antibo...

* Corresponding author. E-mail: [email protected] Background. The aim of the study was to evaluate the association between the most common laboratory markers of thrombophilias and recurrent first-trimester spontaneous abortions. Materials and methods. During the period from November 2000 to April 2004, a case-control study was carried out at the Department of Obstetrics and Gynecology ...

INTRODUCTION Chronic histiocytic intervillositis of unknown etiology (CIUE) is a rare placental inflammatory disease, associated with severe obstetric complications. Its pathophysiologic mechanism remains to be elucidated. AIM To establish anatomical-clinical correlations to improve our understanding of CIUE pathophysiology. MATERIAL AND METHODS Retrospective study of all cases of CIUE occu...

BACKGROUND AND AIMS Anaesthetic practice is associated with a risk of chronic exposure to anaesthetic agents. With the advent of newer inhalational agents and changing anaesthetic practices, the risks for anaesthesiologists with regard to adverse reproductive outcomes is unknown. Hence, a nationwide online survey was conducted to study the anaesthetic practices prevalent in India and their asso...

The release of certain cytokines, e.g. tumour necrosis factor (TNF)-alpha, in the amniotic fluid has been suggested to be a cause of preterm birth. The predisposition to excessive liberation of cytokines from peripheral leukocytes has been shown to depend partly on the individual's HLA-DR genotype. The HLA-DR1 and -DR3 alleles have previously been reported as being associated with a TNF-alpha h...

Coxiella burnetii, an obligate intracellular parasite with a worldwide distribution, is the causative agent of Q fever in humans. We tested a total of 368 samples (placental bits, genital swabs, fecal swabs, and urine and serum samples) collected from women (n = 74) with spontaneous abortions for C. burnetii by a PCR assay targeting IS1111, the repetitive transposon-like region of C. burnetii (...

BACKGROUND Despite well-described histopathologic criteria, the distinction of spontaneous abortion from hydatidiform mole and complete hydatidiform mole from partial hydatidiform mole remains a problem because of interobserver and intraobserver variability. The aim of this study was to evaluate the value of two immunohistochemical markers in the differential diagnosis of subgroups of lesions o...

At least one pregnancy in eight terminates in an abortion recognized as such and recalled by women when asked for a pregnancy history (McDonald, 1958; Warburton and Fraser, 1964). Some women have a greater tendency to abort than others (Warburton and Fraser, 1964) and a few abort repeatedly (Eastman and Hellman, 1961). Gross fetal malformation undoubtedly accounts for some spontaneous abortions...