A variety of nanoscale delivery systems have been shown to enhance the oral absorption of poorly water-soluble and poorly permeable drugs. However, the performance of these systems has seldom been evaluated simultaneously. The aim of this study was to compare the bioavailability enhancement effect of lipid-based nanocarriers with poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) to highl...

Many drug delivery systems have indicated improvement in delivery of various drug molecules and among these biodegradable and biocompatible polymers such as poly(D,L-lactide-co-glycolide) (PLGA) have been shown to enhance intracellular uptake of drug candidates when formulated as nanoparticles. PLGA nanoparticles were prepared by means of a double emulsion solvent evaporation technique and eval...

objective: in dental treatments, use of carriers for targeted antibiotic delivery would be optimal to efficiently decrease microbial count. in this study, gentamicin was loaded into polylactic co-glycolic acid (plga) microspheres and its release pattern was evaluated for 20 days.   methods: in this experimental study, plga microspheres loaded with gentamycin were produced by the w/o/w method. t...

It is of great importance to prepare multifunctional scaffolds combining good mechanical strength, bioactivity, and drug delivery ability for bone tissue engineering. In this study, nanosized mesoporous bioglass/poly(lactic-co-glycolic acid) composite-coated calcium silicate scaffolds, named NMBG-PLGA/CS, were successfully prepared. The morphology and structure of the prepared scaffolds were ch...

PURPOSE To develop a controlled-drug delivery system for the long-term inhibition of vascular endothelial growth factor (VEGF) and its mediated responses. METHODS Poly(lactic-co-glycolic)acid (PLGA) microspheres containing anti-VEGF RNA aptamer (EYE001) formulations in the solid-state were developed by an oil-in-oil solvent evaporation process. In vitro experiments were performed to character...

Sirolimus (SR) is used as an immunosuppressant drug to prevent organ rejection in kidney transplants. It is chemically a macrolide and isolated from the bacterium Streptomyces hygroscopicus in a soil sample. Of recent, it has potent antiproliferative properties and useful in the treatment of certain types of cancer. In our objective of the study, SR is chemically conjugated with Methoxy-polyeth...

AIM In the present investigation, vancomycin (VCM) biodegradable nanoparticles were developed for oral administration, with the aim of improving its intestinal permeability. METHODS The vancomycin-loaded nanoparticles were prepared using double-emulsion solvent evaporation method. The prepared nanoparticles were characterized for their micromeritic and crystallographic properties, particle si...

In treatment of diabetes, it is much desired in clinics and challenging in pharmaceutics and material science to set up a long-acting drug delivery system. This study was aimed at constructing a new delivery system using thermogelling PEG/polyester copolymers. Liraglutide, a fatty acid-modified antidiabetic polypeptide, was selected as the model drug. The thermogelling polymers were presented b...

Background N-acetylcarnosine (NAC), a dipeptide with powerful antioxidant properties that is extensively used as a pharmaceutical prodrug for the treatment of cataract and acute gastric disease, was investigated by molecular dynamics with the GROMACS program in order to understand the solvent effect on peptide conformation of the peptide molecule used as a component of a drug and which presents...

intravitreal injection is the most common approach for drug delivery to the posterior segment in humans. however, following the injection, drugs are rapidly eliminated from the vitreous, with half-lives up to a few days. depending on the rate of clearance from the vitreous, large boluses and frequent administrations may be required to ensure therapeutic levels over an extended period of time. m...