Correct orientation of the mitotic spindle in stem cells underlies organogenesis. Spindle abnormalities correlate with cancer progression in germ line-derived tumors. We discover a macromolecular complex between the scaffolding protein Gravin/AKAP12 and the mitotic kinases, Aurora A and Plk1, that is down regulated in human seminoma. Depletion of Gravin correlates with an increased mitotic inde...

BACKGROUND Cellular angiofibroma is a rare benign mesenchymal neoplasm with morphological and immunohistochemical similarities to spindle cell lipoma. Karyotypic information on cellular angiofibroma is restricted to one case only which showed loss of material from chromosomes 13 and 16. A few other studies using fluorescence in situ hybridization showed deletions of the RB1 and FOXO1 loci, both...

Kidney mucinous tubular and spindle cell carcinoma (MTSpCC) is a rare renal low-grade pleomorphic epithelial neoplasm featured by tubular and spindle cells with a relatively indolent behavior. This study was designed to clinicopathologically characterize two cases of kidney MTSpCC. Similar to other tumors, the data showed the diagnosis of MTSpCC relies on histological examination. Tumor cells s...

Spindle cell neoplasms of the upper respiratory tract and oral cavity are unique lesions which pose not only therapeutic problems for the clinician but also difficult interpretive problems for the pathologist. Because of their bizarre microscopic appearance they have frequently been interpreted as sarcomas; however, recent studies suggest that most of these neoplasms are squamous cell carcinoma...

INTRODUCTION Spindle cell rhabdomyosarcoma of the head and neck is a very rare tumor in adults. We report on one case with long-term survival. CASE PRESENTATION A 41-year-old nonsmoking Caucasian man presented in June 2007 with a painless swelling under his tongue. A diagnosis of a soft tissue sarcoma, and a myofibrosarcoma in particular, was made via biopsy. After multimodal treatment, inclu...

Abstract Background Giant cell tumor is a of benign nature which usually arises in the long bone, but it can also be seen at unusual sites. Only few cases have been reported so far regarding involvement greater trochanter femur as very divergent site for giant tumors; our case one them. tumors are 20–40 years age metaepiphyseal regions bones. If has to involved, distal end usually. Case present...

Spindle cell hemangioma (SCH) is a rare benign vascular tumor and we report 2 cases of SCH who are 50-year-old man and 16-year-old girl. A growing amount of evidence indicates that multifunctional ECM molecule decorin regulate endothelial cell-matrix interactions during angiogenesis. Furthermore, a current publication shows that no detectable decorin expression was found in the stromas of tumor...

Myofibromas are benign uncommon fibroblastic tumors of the soft tissue, bone, or internal organs affecting all ages. These lesions histopathologically may mimic many other soft tissue tumors of the oral cavity such as spindle cell tumors of neurogenic and smooth muscle cell origin, thus leading to misdiagnosis and mistreatment. This case report describes a rare benign tumor, which presented as ...

OBJECTIVES Fine-needle aspiration cytology serves as a rapid and cost-effective tool for the diagnosis of melanoma, especially in the recurrent and metastatic cases. The diagnosis poses a challenge due to the varied morphological patterns. Spindle cell melanoma mimics other sarcomas and carcinomas on morphology. This study highlights the cytomorphological features of spindle cell melanoma and c...