background and objectives: biofilm formation is an important virulence factor for methicillin-resistant staphylococcus aureus (mrsa). fosfomycin is a borad-spectrum antibiotic with inhibitory effects on biofilm production and β-chloro-l-alanine (β-cla) is an amino acid analog. the aim of this study was to determine effect of the combination of fosfomycin and β-cla on biofilm production by mrsa ...

in this paper, the structure of a new 16-membered macrocyclic schiff base compound n,n′-(3,3′-dimethoxy-2,2′-(propane-1,3-diyldioxy)dibenzylidene)propane-1,3-diamine, c22h26n2o4 (1), derived from 1,3-propanediamine and 3,3′-dimethoxy-2,2′-(propane-1,3-diyldioxy)dibenzaldehyde has been studied by single crystal x-ray diffraction, dft calculations at b3lyp/6-31g** and ft-ir spectroscopy. the titl...

We consider a class of two-dimensional Schrödinger operator with a singular interaction of the δ type and a fixed strength β supported by an infinite family of concentric, equidistantly spaced circles, and discuss what happens below the essential spectrum when the system is amended by an Aharonov-Bohm flux α ∈ [0, 1 2 ] in the center. It is shown that if β ̸= 0, there is a critical value αcrit ∈...

Environmental microorganisms represent the most relevant reservoir of resistance to antibiotics in the community, and this is due in part to the undue exposure of these organisms to antimicrobial agents. AmpC β-lactamases are clinically important cephalosporinases encoded on the chromosomes of bacteria in the Enterobacteriaceae family and some non-enteric bacteria including Pseudomonas aerugino...

Trifluoromethylated organic compounds, especially chiral quaternary alcohols bearing trifluoromethyl group are of important intermediates in drugs, agrochemicals and etc.An efficient epoxidation of β-CF3-β,β-disubstituted unsaturated ketones (6) has been developed with environmental benign hydrogen peroxide as the oxidant and F5-substituted chiral qua...

We studied the prevalence of ceftazidime resistance in Pseudomonas aeruginosa and the rates of extended-spectrum β-lactamase (ESBL), AmpC β-lactamase (AmpC) and metallo-β-lactamase (MBL) production among the ceftazidime resistant Pseudomonas aeruginosa. A very high rate of MBL production was observed, which suggested it to be an important contributing factor for ceftazidime resistance among Pse...

results of the 100 klebsiella isolates, 41 (41%) demonstrated resistance or reduced susceptibility to ceftazidime and/or aztreonam and 35% (n = 35) were esbl-producers. twenty-eight (8o%) of the esbl-producing isolates carried the blactx-m type genes. based on pcr assays and sequencing of blactx-m genes, ctx-m-1, ctx-m-2 and ctx-m-9 were identified in 21 (60%), 15 (42%) and nine (34%) of these ...