One of the most promising applications of microarrays is class distinction through gene expression profiling as a diagnostic tool. However, as there is apparent spatial heterogeneity in the morphology of cancer cells within a tumor, it is unclear if tumor sampling can be applied and yield consistent signals. In this report, we examined six brain tumors, four glioblastoma, and two oligodendrogli...

Inter-subject fMRI analyses have specific issues regarding the reliability of the results concerning both the detection of brain activation patterns and the estimation of the underlying dynamics. Among these issues lies the variability of the hemodynamic response function (HRF), that is usually accounted for using functional basis sets in the general linear model context. Here, we use the joint...

Satellite imagery is being used increasingly in association with national forest inventories (NFIs) to produce maps and enhance estimates of forest attributes. We simulated several image spatial resolutions within sparsely and heavily forested study areas to assess resolution effects on estimates of forest land area, independent of other sensor characteristics. We spatially aggregated 30 m data...

Propagating neural activity in the developing mammalian retina is required for the normal patterning of retinothalamic connections. This activity exhibits a complex spatiotemporal pattern of initiation, propagation, and termination. Here, we discuss the behavior of a model of the developing retina using a combination of simulation and analytic calculation. Our model produces spatially and tempo...

Statistically downscaled climate data have been widely used to explore possible impacts of climate change in various fields of study. Although many studies have focused on characterizing differences in the downscaling methods, few studies have evaluated actual downscaled datasets being distributed publicly. Spatially focusing on the Pacific Northwest, we compare five statistically downscaled cl...

In this article, we present a new statistical methodology for longitudinal studies in forestry, where trees are subject to recurrent infection, and the hazard of infection depends on tree growth over time. Understanding the nature of this dependence has important implications for reforestation and breeding programs. Challenges arise for statistical analysis in this setting with sampling schemes...

Concussion is a major health concern, associated with short-term deficits in physical function, emotion and cognition, along with negative long-term health outcomes. However, we remain in the early stages of characterizing MRI markers of concussion, particularly during the first week post-injury when symptoms are most severe. In this study, 52 varsity athletes were scanned using Magnetic Resona...

In the present study, analytical solutions are obtained for two-dimensional advection dispersion equation for conservative solute transport in a semi-infinite heterogeneous porous medium with pulse type input point source of uniform nature. The change in dispersion parameter due to heterogeneity is considered as linear multiple of spatially dependent function and seepage velocity whereas seepag...

Human leg muscles are often activated inhomogeneously, e.g. in standing. This may also occur in complex tasks like walking. Thus, bipolar surface electromyography (sEMG) may not accurately represent whole muscle activity. This study used 64-electrode high-density sEMG (HD-sEMG) to examine spatial variability of lateral gastrocnemius (LG) muscle activity during the stance phase of walking, maxim...

The interaction of jets with topography in the Southern Ocean is investigated using 19 years of altimetry data. In particular, the ‘‘jet jumping’’ mode of variability, by which two or more jets passing close to the same topographic feature show strongly anticorrelated strengthening and weakening, is studied. Three regional case studies are described—the Southeast Indian Ridge south of Tasmania,...