The formation, isolation, and characterizat,ion of two isomeric, inactive derivatives of ribonuclease, l-carboxymethylhistidinc119and 3-carboxymethylhistidine-12-ribonuclease,1 were dcscribed in the preceding paper (2). Studies on the course of the alkylation reaction and on some of the properties of the two alkylated derivatives are the subject of the present communication. It has been found t...