5S rRNA is a ribosomal core component, transcribed from many gene copies organized in genomic repeats. Some eukaryotic species have two 5S rRNA types defined by their predominant expression in oogenesis or adult tissue. Our next-generation sequencing study on zebrafish egg, embryo, and adult tissue identified maternal-type 5S rRNA that is exclusively accumulated during oogenesis, replaced throu...

An accurate classification of human cancer, including its primary site, is important for better understanding of cancer and effective therapeutic strategies development. The available big data of somatic mutations provides us a great opportunity to investigate cancer classification using machine learning. Here, we explored the patterns of 1,760,846 somatic mutations identified from 230,255 canc...

Many generations of biologists have been intrigued by the myriad structures that eukaryotic chromosomes can adopt and have questioned how their form relates to function [1,2]. One organizational state that chromosomes adopt is pairing in a homology-dependent manner [3–8]. Although homolog pairing in meiosis has been extensively studied and is important for chromosome segregation, pairing of hom...

background: the infertility is an important health problem, affecting about 15% of couples. the important role of genetic factors in pathogenesis of infertility is now increasingly recognized. the value of karyotyping women in the routine work-out of couples referred for sterility has long been recommended. objective: the aim of this study was to define the frequency of all chromosomal aberrati...

The clinical, cytogenetic and dermatoglyphic findings in a patient with a ring chromosome 21 are presented. This anomaly acts as a deletion of chromosomal material and results in specific congenital defects. A comparison is made with 24 cases of deletions involving chromosome 21 described in the literature. Six of these have been studied by means of recently developed chromosome banding techniq...

The breakpoint of t(11;14)(q23;q32) chromosome translocation in a B-cell lymphoma line, RC-K8, was cloned. Immunoglobulin heavy chain (IGH) constant gene, C gamma 2 at the 5' end, was involved in this translocation, and the DNA segment juxtaposed to the C gamma 2 was proved to be derived from chromosome 11 by somatic cell hybrid study. The normal counterpart of chromosome 11 was also isolated. ...

The 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P-450 gene family (P1-450 and P3-450 in the C57BL/6N mouse) has recently been localized to mouse chromosome 9. In the present study, HindIII-digested DNA from Chinese hamster, mouse, and 20 Chinese hamster X mouse somatic cell hybrids and subclones segregating hamster chromosomes was probed with the mouse P1-450 and P3-450 full-length...

The detection and mapping of genetic markers linked to quantitative trait loci (QTL) can be utilized to enhance genetic improvement of livestock populations. With the completion of the bovine genome sequence assembly, single nucleotide polymorphisms (SNP) assays spanning the whole bovine genome and research work on large scale identification, validation and analysis of genotypic variation in ca...

A model of En transposition during chromosome replication is presented following a study of somatic events associated with the transposition of En in the endosperm tissue of the maize kernel. Two supporting assays, the excision and the postexcision events, were used in following these events. The excision of the En transposon has been monitored in the starch-producing endosperm tissue by using ...