Abstract Heart disease and hypertension are two of the main causes human mortality worldwide. Both can be caused by oxidation cholesterol, causing plaque narrow blood vessels. The purpose this research was to determine solvent for extraction antioxidant anticholesterol bioactive compounds from bekasam extracts. Bekasam extracted polar solvents, i.e., aquabides, methyl alcohol (methanol), ethyl ...

Abstract: Solid dispersion (SD) is one of the oldest and widely utilized techniques to improve solubility slowly dissolving drugs. A variety pharmaceutically compatible additives using different emerging technology used for preparing SDs. Multiple approaches were designed prepare SDs by such as kneading, co-milling, fusion, solvent evaporation various solvent-associated methods. The selection a...

Distillation-based separation processes, such as extractive or heteroazeotropic distillation, present important processes for separating azeotropic mixtures in the chemical and biochemical industry. However, distillation has received much less attention than which can be attributed to multiple reasons. The phase equilibrium calculations require a correct evaluation of stability, while topology ...

The consideration of discrete variables (e.g. catalyst, ligand, solvent) in experimental self-optimization approaches remains a significant challenge. Herein we report the application new mixed variable multi-objective optimization (MVMOO) algorithm for chemical reactions. Coupling MVMOO with an automated continuous flow platform enabled identification trade-off curves different performance cri...

Selecting suitable cleaning agents and determining justifiable cleaning process parameters are critical prerequisites for cleaning validation. Proper selection of these cleaning agents and parameters could simplify cleaning validation efforts immensely. Process cleaners may range from a single component, such as an organic solvent, to multicomponent formulations that use multiple cleaning mecha...

The heavy-metal-free photocatalytic system, in which carbon nitride is coated on polylactic acid (PLA) as biodegradable plastic through a simple dip coating method, was used for dye decomposition under visible light irradiation. Solvent selection, solvent concentration, and the number of coatings were investigated to optimize conditions loading PLA. Carbon cannot be PLA water, but it can strong...

In bioprocesses lipases are typically used in immobilized form, irrespective of type of reaction systems, to ensure an even distribution of catalysts in water restricted media and/or to facilitate separation and reuse. In these studies we report on the selection of appropriate enzyme-carrier preparation for hydrolysis reaction in aqueous and biphasic systems and transesterification in organic s...

The central importance of solvent interactions in stabilization of specific protein structure has long been recognized. Decades ago, Tanford and Kirkwood treated in detail the interaction of charges with solvent, and they showed how desolvation/burial of charges upon protein folding was an important factor in stability.1 The influence of their model, with further elaborations, can still be seen...