نتایج جستجو برای: soluble aβ1 42
تعداد نتایج: 198217 فیلتر نتایج به سال:
Psychosis is reported over 30% of patients with Alzheimer's disease (AD) in clinics. Aripiprazole is an atypical antipsychotic drug with partial agonist activity at the D2 dopamine and 5-HT1A receptors with low side-effect profile. We identified aripiprazole is able to overcome the amyloid-β (Aβ)-evoked neurotoxicity and then increase the cell viability. This study elucidated the mechanism(s) b...
Amyloid-β peptide (Aβ) is known to be directly associated with the progressive neuronal death observed in Alzheimer’s disease (AD). However, effective neuroprotective approaches against Aβ neurotoxicity are still unavailable. In the present study, we investigated the protective effects of Akebia saponin D (ASD), a typical compound isolated from the rhizome of Dipsacus asper Wall, on Aβ1–42-indu...
Alzheimer’s disease (AD) is the most common neurodegenerative disease among the elderly and accounts for 60-80% of all cases of dementia. Currently, the diagnosis of AD is based on cognitive tests and mental state exams, but the peptide amyloid-beta (Aβ) in cerebrospinal fluid (CSF) is increasingly used in clinical trials and settings. As for most protein and peptide biomarkers, quantification ...
Background:Amyloid-beta (Aβ), is one of the risk factors of Alzheimer’s disease (AD) that increases in diabetes. The aim of this study was to investigate the effect of 6 weeks of voluntary wheel running with Allium paradoxum supplementation on plasma Amyloid beta1-42 in the diabetic rats induced with Alloxan. Methods: In this laboratory experimental study 28 male ratsweighing 185±1 gm...
Cognitive impairment in Alzheimer's disease (AD) patients is associated with a decline in the levels of growth factors, impairment of axonal transport and marked degeneration of basal forebrain cholinergic neurons (BFCNs). Neurogenesis persists in the adult human brain, and the stimulation of regenerative processes in the CNS is an attractive prospect for neuroreplacement therapy in neurodegene...
BACKGROUND Studies conducted in animal models and humans suggest the presence of a dynamic equilibrium of amyloid-β (Aβ) peptide between cerebrospinal fluid (CSF) and plasma compartments. OBJECTIVE To determine whether plasma exchange (PE) with albumin replacement was able to modify Aβ concentrations in CSF and plasma as well as to improve cognition in patients with mild-moderate Alzheimer's ...
BackgroundPostoperative neurocognitive decline is a frequent complication in adult patients undergoing major surgery with increased risk for morbidity and mortality. The mechanisms behind cognitive after anaesthesia are not known. We studied the association between CSF blood biomarkers of neuronal injury or brain amyloidosis long-term changes function.MethodsIn orthopaedic (knee hip replacement...
Background: Tissue type 2 transglutaminase (TG2, E.C. 2.3.2,13) is reported to be involved in the phagocytosis of apoptotic cells mouse microglial BV2 and peripheral macrophages. In this study, by using lipopolysaccharide (LPS)- or amyloid-β 1-42 (Aβ 1-42) peptide-stimulated cell line primary cells, we examined effects different neuronutraceutical compounds, such as curcumin (Cu) N-Palmitoyleth...
Alzheimer's disease (AD) is associated with the pathological self-assembly of amyloid-β (Aβ) peptides into β-sheet enriched fibrillar aggregates. Aβ dimers formed in the initial step of Aβ aggregation were reported to be the smallest toxic species. Inhibiting the formation of β-sheet-rich oligomers and fibrils is considered as the primary therapeutic strategy for AD. Previous studies reported t...
Alzheimer's disease is the most common form of senile dementia in world, and amyloid β peptide1-42 (Aβ1-42) one its two principal biological hallmarks. While interactome concept was getting forward scientific community, we proposed that study molecular interactions peptide with membranes will allow to highlight underlying mechanisms responsive AD. We have developed simple liposomal formulations...
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