Loratadine, a Class II drug is a second generation antihistaminic agent, which is poorly water soluble with low bioavailability. Loratadine is practically insoluble in water and as such it exhibits poor variable oral bioavailability. Loratadine needs enhancement of solubility and dissolution rate to improve its oral bioavailability and therapeutic efficacy. In the present investigation, studies...

Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL). In this review, several major nanonization techniques that seek to overcome these limita...

Solubility of pharmaceutical drugs in organic solvents is one the important parameters to understand equilibrium concentration solute-solvent, which helps optimize and design crystallization conditions obtain desired product crystals. In present study, Chlorzoxazone (CHZ) used as a model compound investigate solubility, influence solvent operating on shape, size distribution. The solubility CHZ...

In 1925, Holt, La Mer, and Chown (1) reported that the apparent solubility product [Ca++13[P04=J2 was greater in a solution of inorganic salts approximating the composition of serum than it was in solutions of sodium chloride of the same ionic strength. Very shortly thereafter, Sendroy and Hastings (2) recalculated values for pK’, Ca,(PO& from the data of Holt, La Mer, and Chown and also report...

A series of basic carboxamides of actagardine (1), a lantibiotic possessing good antistreptococcal activity, were synthetized. Some physico-chemical characteristics, in particular charge and lipophilicity, that influence water solubility were determined. The in vitro and in vivo activity was evaluated. The monocarboxamides were generally more active than actagardine against selected Gram-positi...

This paper describes an experimental procedure recently developed to simulate and study the behaviour of various chemicals in seawater during their transfer in a 5 m deep water column. Since chemical pollution can be harmful to the environment, anticipating the evolution of a chemical spill is important for authorities, so that they can act rapidly and efficiently after a spill. In the case of ...