نتایج جستجو برای: sofosbuvir
تعداد نتایج: 1451 فیلتر نتایج به سال:
Background and aims Treatment of hepatitis C virus (HCV) changed dramatically with the introduction of oral direct-acting antiviral drugs due to their high antiviral potency and safety profile. Sofosbuvir plus daclatasvir combination therapy was extensively investigated in HCV genotypes 1, 2, and 3, while published data regarding its real-life application in the treatment of genotype 4 is lacki...
BACKGROUND & AIMS In Taiwan, patients with chronic hepatitis C virus (HCV) infection are currently treated with pegylated interferon-alpha plus ribavirin, but interferon-based regimens can be poorly tolerated, especially by those with advanced liver disease and the elderly. Sofosbuvir, an oral nucleotide analogue inhibitor of HCV NS5B polymerase, is approved in Europe, the USA and Japan for tre...
OBJECTIVES Development of direct acting antivirals (DAA) offers new benefits for patients with chronic hepatitis C. The combination of these drugs with antiretroviral treatment (cART) is a real challenge in HIV/HCV coinfected patients. The aim of this study was to describe potential drug-drug interactions between DAAs and antiretroviral drugs in a cohort of HIV/HCV coinfected patients. METHOD...
conclusions if such a regimen is approved, it would be a breakthrough in the treatment of hcv in subjects with hemoglobinopathy. more prospective, randomized control trial studies are needed to investigate the efficacy and safety profile of such a regimen. case presentation we described a 16- year-old male patient with sickle-thalassemia who was infected with a hcv. treatment was started with s...
he investigation by The BMJ and Cambridge and Bath universities into the availability of breakthrough hepatitis C drugs raises important questions for NHS England about access to lifesaving drugs. But why are medicines so expensive in the first place? The pricing strategy of Gilead for sofosbuvir (Sovaldi) and ledipasvir-sofosbuvir (Harvoni) raises questions that go well beyond the UK. The BMJ'...
Abstract Background Hepatitis C virus (HCV) is a contagious disease that damages the liver over time, eventually leading to cirrhosis and death. Chronic HCV infection regarded as serious health problem worldwide, impacting up 3% of populace killing 300,000 people annually. Quick reproduction driven by non-structural protein 5B (NS5B), which possible target spot for development anti-HCV vaccines...
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection and treatment are significant health organizations’ concerns worldwide. Although there is no proven drug license against the virus, a variety of components have under investigation. Objectives: In this regard, present study was intended to evaluate consequences Sovodak (sofosbuvir/ daclatasvir) in COVID-19 patie...

 Clinical evidence showed that treatment with glecaprevir-pibrentasvir for children and adolescents chronic hepatitis C virus infection was efficacious an overall sustained virologic response 12 weeks after near 100%.
 Glecaprevir-pibrentasvir well-tolerated as there were no serious adverse events or leading to discontinuation. Most mild.
 We did not find any studies evaluated t...
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