In view of the increasing importance of reduced sulfur compounds in biological chemistry, a study of the nitroprusside reaction was recently made in this laboratory in an attempt to render the reaction more specific for compounds of the type C-S-H, since sodium nitroprusside in alkaline solution not only gives coloration with compounds of this type but also with ketones, aldehydes, creatinine, ...

The effect of intra-arterial sodium nitroprusside infusions on acute experimental basilar artery spasm was studied in dogs. Vasospasm produced by subarachnoid hemorrhage at normal intracranial pressure was partially relieved by nitroprusside. When given by the intra-arterial route, 15 times the recommended maximum intravenous does can be infused without significant hypotension or elevation in i...

Nitric oxide (NO) may mediate some of the toxic effects of the excitatory amino acid (EAA) glutamate when there is overactivation of the N-methyl-D-aspartate (NMDA) receptor. In the developing rodent nervous system, NMDA neurotoxicity peaks at postnatal day 7. To assess whether NO toxicity exhibits a similar developmental profile, we injected the NO generator sodium nitroprusside into the immat...

We would like to salute the authors of the article published in the Arquivos Brasileiros de Cardiologia , Vol. 99, No. 3, in September 2012, under the title of Sildenafil vs. Nitroprussiato de Sódio Durante Teste de Reatividade Pulmonar PréTransplante Cardíaco (Sildenafil vs. Sodium Nitroprusside During Pulmonary Reactivity Test Before Heart Transplantation). While studying and discussing the a...

OBJECTIVE Evaluate the ability of clonidine to reduce pulmonary arterial pressure in patients with pulmonary hypertension undergoing heart surgery, either by reducing the pressure values from the direct measurement of pulmonary arterial pressure or by reducing or eliminating the need for intraoperative dobutamine and nitroprusside. METHOD Randomized, double-blind, placebo-controlled, comparat...