The human SLC4A5 gene has been identified as a hypertension susceptibility gene based on the association of single nucleotide polymorphisms with blood pressure (BP) levels and hypertension status. The biochemical basis of this association is unknown particularly since no single gene variant was linked to hypertension in humans. SLC4A5 (NBCe2, NBC4) is expressed in the collecting duct of the kid...

INTRODUCTION Contrast-induced nephropathy is one of the main causes of acute kidney injury and increased hospital-acquired morbidity and mortality. The use of sodium bicarbonate for nephroprotection has emerged as a preventative strategy; however, its efficacy is controversial compared to other strategies, such as hydration using 0.9% saline solution. OBJECTIVE To compare the effectiveness of...

1 Rhee KH, Toro LO, McDonald GG, Nunnally RL, Levin DL. Carbicarb, sodium bicarbonate, and sodium chloride in hypoxic lactic acidosis: effect on arterial blood gases, lactate concentrations, hemodynamic variables, and myocardial intracellular pH. Chest 1993; 104:913-18 2 Sonett J, Baker LS, Hsi C, Knox MA, Visner MS, Landow L. Sodium bicarbonate versus carbicarb in canine myocardial hypercarbic...

The present study was carried out with an objective of preparation and in vitro evaluation of floating tablets of hydroxypropyl methyl cellulose (HPMC) and polyethylene oxide (PEO) using ranitidine hydrochloride as a model drug. The floating tablets were based on effervescent approach using sodium bicarbonate a gas generating agent. The tablets were prepared by dry granulation method. The effec...

Purpose The aim of the present narrative review was to consider the evidence on the timing, optimal dose and intake duration of the main dietary supplements β-alanine, nitrate, caffeine, creatine, sodium bicarbonate, carbohydrate and protein. Methods This review article will focuses on timing, optimal dose and intake duration of main dietary supplements for consuming. Results This paper rev...

Previous functional studies have demonstrated that muscle intracellular pH regulation is mediated by sodium-coupled bicarbonate transport, Na+/H+ exchange, and Cl-/bicarbonate exchange. We report the cloning, sequence analysis, tissue distribution, genomic organization, and functional analysis of a new member of the sodium bicarbonate cotransporter (NBC) family, NBC3, from human skeletal muscle...

90 Abstract Introduction: Contrast-induced nephropathy is one of the main causes of acute kidney injury and increased hospital-acquired morbidity and mortality. The use of sodium bicarbonate for nephroprotection has emerged as a preventative strategy; however, its efficacy is controversial compared to other strategies, such as hydration using 0.9% saline solution. Objective: To compare the effe...

Introduction: Air-powder polishing devices are increasingly used for stain and plaque removal. However, besides cleaning the tooth surface, they may increase the surface roughness of the dental tissues. This in turn may result in plaque accumulation and superficial degradation. Thus the aim of this study was to assess the influence of three different abrasive agents: Pumice, Sodium bicarbonate ...

INTRODUCTION The purpose of this prospective, randomized, double-blind study was to evaluate the effect of a buccal infiltration of sodium bicarbonate on the anesthetic success of the inferior alveolar nerve block (IANB) for mandibular first molars in patients with symptomatic irreversible pulpitis. METHODS One hundred patients diagnosed with symptomatic irreversible pulpitis of a mandibular ...

The present study describes the hydrochemistry of ground waters found in Mesta River Basin, located south-western part Bulgaria. groundwater’s composition can be expressed as follows: Ca2+ > Na+ Mg2+ K+; K+ equivalent units for cations, and HCO3– SO42– Cl– anions. chemical studied groundwater described calcium-bicarbonate. calcium ions make up from 17.90% to 38.62% (30.18% on average), bicar...