A typical problem associated to Monte Carlo developments and application consists in the validation of the simulation models and results against experimental data. A novel software toolkit has been developed encompassing an ample variety of statistical algorithms for the comparison of data distributions, such as Monte Carlo simulations and experimental data. The toolkit contains a variety of go...

Four sets of experimental data were investigated in terms of normal distribution and presence of outliers. The following sets of compound were investigated: blood-brain barrier partitioning (n=105), inhibitory activity of para-substituted aromatic sulfonamides (n=47), inhibition activity of taxoids (n=63), and estrogen receptor binding affinity of triphenilacrylonitriles (n=25). The normality o...

We introduce a nonparametric test intended for large-scale simultaneous inference in situations where the utility of distribution-free tests is limited because of their discrete nature. Such situations are frequently dealt with in microarray analysis where the number of tests is much larger than the sample size. The proposed test statistic is based on a certain distance between the distribution...

MOTIVATION Several statistical tests are available to detect the enrichment of differential expression in gene sets. Such tests were originally proposed for analyzing gene sets associated with biological processes. The objective evaluation of tests on real measurements has not been possible as it is difficult to decide a priori, which processes will be affected in given experiments. RESULTS W...

Until 6 October 2005 sixteen redshifts have been measured of long gamma-ray bursts discovered by the Swift satellite. Further 45 redshifts have been measured of the long gamma-ray bursts discovered by other satellites. Here we perform five statistical tests comparing the redshift distributions of these two samples assuming as the null hypothesis identical distribution for the two samples. Three...

Brinker is the key target protein of the Drosophila Decapentaplegic morphogen signalling pathway. Brinker is widely expressed and can bind with DNA. NMR spectra suggest that apo-Brinker is intrinsically unstructured and undergoes a folding transition upon DNA-binding. However, the coupled mechanism of binding and folding is poorly understood. Here, we performed molecular dynamics (MD) simulatio...

Extended Abstract. Suppose n i.i.d. observations, X1, …, Xn, are available from the unknown distribution F(.), goodness-of-fit tests refer to tests such as H0 : F(x) = F0(x) against H1 : F(x) $neq$ F0(x). Some nonparametric tests such as the Kolmogorov--Smirnov test, the Cramer-Von Mises test, the Anderson-Darling test and the Watson test have been suggested by comparing empirical ...

In this paper we study stochastic processes which enable monitoring the possible changes of probability distributions over time. These so-called monitoring processes are bivariate functions of time and position at the measurement scale, and in particular be used to test the null hypothesis of no change: one may then form Kolmogorov–Smirnov or other type of tests as functionals of the processes....

In this paper we consider two independent iid samples X1, ...., Xm and Y1, ...., Yn, a given class of functions Λ, and perform the test • H0: There exists λ ∈ Λ such that λ(Y1) has the same distribution as X1. • H1: non H0. We present tests of the Kolmogorov-Smirnov type and smooth alternatives based on Von Mises calculus. Algorithms for some particular cases are provided. Our procedure may be ...