نتایج جستجو برای: smads
تعداد نتایج: 965 فیلتر نتایج به سال:
The cardiovascular system is the first functional organ system to develop in the vertebrate embryo. It starts out with differentiation of mesodermal cells into hemangioblasts, bipotential stem cells capable of development into hematopoietic and endothelial lineages. Angioblasts form a primitive vascular plexus de novo in a process known as vasculogenesis. New blood vessels form by angiogenesis,...
Transforming Growth Factor(TGF) is the prototype of a superfamily of multifunctional proteins which includes activins and bone morphogenetic proteins (BMPs). TGFis involved in the regulation of diverse cellular processes such as cell proliferation, differentiation, apoptosis and migration, as well as moderating cell–cell and cell–matrix interactions. It plays a pivotal role in embryonic develop...
Bone morphogenetic proteins, BMPs, are members of the transforming growth factor-beta (TGF-beta) superfamily, which are implicated in embryogenesis, organogenesis, skeletogenesis, osteogenesis, cellular differentiation and apoptosis by regulating the expression of specific target genes. Recent progresses in studying the BMP signaling reveal that a cytoplasmic protein family, Smad, plays a centr...
Transforming growth factor β (TGF-β) and related growth factors are secreted pleiotropic factors that play critical roles in embryogenesis and adult tissue homeostasis by regulating cell proliferation, differentiation, death, and migration. The TGF-β family members signal via heteromeric complexes of type I and type II receptors, which activate members of the Smad family of signal transducers. ...
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