Chemical conjugates comprising synthetic Toll-like receptor ligands (TLR-L) covalently bound to antigenic synthetic long peptides (SLP) are attractive vaccine modalities, which can induce robust CD8(+) T-cell immune responses. Previously, we have shown that the mechanism underlying the power of TLR-L SLP conjugates is improved delivery of the antigen together with a dendritic cell activation si...

Sulfolipopolysaccharides (SLPs) were synthesized by reaction of the synthetic polysucrose polymer Ficoll-400 with chlorosulfonic acid and lauroyl chloride in anhydrous medium. Hydrophobic derivatives were obtained by addition of a small number of sulfate and a large number of lipid groups. Gel-permeation high-performance liquid chromatography (g.p.-h.p.l.c.) exhibited a wide range in molecular ...

Campylobacter fetus causes gastrointestinal and systemic infections in humans. Although relapse is common despite antibiotic treatment, the mechanisms are not well understood. The surface-layer proteins (SLPs) of C. fetus, which are critical in virulence, undergo high-frequency phenotypic switching due to recombination of sap homologues, resulting in antigenic variation. To investigate the mech...

Saposin-like proteins (SAPLIPs) from soil-transmitted helminths play pivotal roles in host-pathogen interactions and have a high potential as targets for vaccination against parasitic diseases. We have identified two non-orthologous SAPLIPs from human and dog hookworm, Na-SLP-1 and Ac-SLP-1, and solved their three-dimensional crystal structures. Both proteins share the property of membrane bind...

Recent advances in neural network modeling have led to the nonlinear generalization of classical multivariate analysis techniques such as principal component analysis and canonical correlation analysis (CCA). The nonlinear canonical correlation analysis (NLCCA) method is used to study the relationship between the tropical Pacific sea level pressure (SLP) and sea surface temperature (SST) fields...

The B cell antigen receptor (BCR) consists of the membrane-bound immunoglobulin (Ig) molecule as antigen-binding subunit and the Ig-alpha/Ig-beta heterodimer as signaling subunit. BCR signal transduction involves activation of protein tyrosine kinases (PTKs) and phosphorylation of several proteins, only some of which have been identified. The phosphorylation of these proteins can be induced by ...

Human stomatin (band 7.2b) is a 31-kDa erythrocyte membrane protein of unknown function but implicated in the control of ion channel permeability, mechanoreception, and lipid domain organization. Although absent in erythrocytes from patients with hereditary stomatocytosis, stomatin is not linked to this disorder. A second stomatin homologue, termed SLP-1, has been identified in nonerythroid tis...

Multistage Stochastic Linear Programming (SLP) suffers from scenario explosion as the number of stages or the number of stochastic parameters increases. In this case, either one solves the SLP model approximately or one solves an approximation to the SLP model. In this situation it is useful to have some cost bound in order to assess the quality of approximated solutions. In this paper we intro...

C4 and Slp are highly homologous mouse genes that differ in function and regulation. Allelic variants exist in quantitative regulation of C4 and in hormonal regulation of Slp. We have examined expression in several tissues, including liver and peritoneal macrophages which are the major sites of synthesis, using a probe that allows direct comparison of C4 and Slp mRNAs. Correctly-sized and initi...

‎in this paper‎, ‎we find matrix representation of a class of sixth order sturm-liouville problem (slp) with separated‎, ‎self-adjoint boundary conditions and we show that such slp have finite spectrum‎. ‎also for a given matrix eigenvalue problem $hx=lambda vx$‎, ‎where $h$ is a block tridiagonal matrix and $v$ is a block diagonal matrix‎, ‎we find a sixth order boundary value problem of atkin...