Ser/thr phosphorylation is the primary reversible covalent modification of proteins in eukaryotes. As a consequence, it is the reciprocal actions of kinases and phosphatases that act as key molecular switches to fine tune cellular events. It has been well documented that ~400 human ser/thr kinases engage substrates via consensus phosphosite sequences. Strikingly, we know comparatively little ab...

The authors develop slim and light-weight vacuum insulation panels (VIPs) by producing vacuum layers with spacers and plastic plates. The developed VIPs have the advantages of a low cost and easy installation, thus facilitating retrofitting insulation of existing buildings. In addition, one of the developed VIPs is slim and translucent so it can be easily used for windows in an internal install...

This paper describes a new mesh-connected SIMD architecture, called a Sliding Memory Plane (SIiM) Array Processor. On SIiM, the inter-processing element (inter-PE) communication, using the sliding memory plane, and the data input/output (I/O), using two U 0 planes, can occur without interrupting the PE’s, which greatly diminishes the communication and I/O overhead. SliM is unique in its ability...

Unlike traditional recommendation systems that rely only on the user's preferences, context-aware (CARS) consider contextual information such as (time, weather, and geographical location). These data are used to create more intelligent effective systems. Time is one of most important influential factors affect users’ preferences purchasing behavior. Thus, in this paper, time-aware investigated ...