نتایج جستجو برای: slco1b1

تعداد نتایج: 546  

2014
Jasmine A Talameh Joseph P Kitzmiller

Statins are the most commonly prescribed drugs in the United States and are extremely effective in reducing major cardiovascular events in the millions of Americans with hyperlipidemia. However, many patients (up to 25%) cannot tolerate or discontinue statin therapy due to statin-induced myopathy (SIM). Patients will continue to experience SIM at unacceptably high rates or experience unnecessar...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2010
Rune Amundsen Hege Christensen Behnaz Zabihyan Anders Asberg

The aim of this study was to investigate the potential of calcineurin inhibitors [cyclosporine A (CsA) and tacrolimus (Tac)] to inhibit cellular uptake of atorvastatin mediated by the liver-specific organic anion-transporting polypeptide 1B1 (OATP1B1) in vitro. Patients with solid organ transplants are frequently treated with HMG-CoA reductase inhibitors (statins). CsA increases atorvastatin sy...

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