The erbB family of receptor tyrosine kinases are known to play important roles in normal epithelial development and epithelial neoplasia. Considerable evidence also suggests that signaling through the epidermal growth factor receptor (EGFR) plays an important role in multistage skin carcinogenesis in mice; however, less is known about the role of erbB2. In this study, to further examine the rol...

Neurofibroma, a common benign tumor in soft tissue, continues to grow, and often appears to be giant. In this study, we retrospectively analyzed the surgical treatment of 26 patients with giant neurofibromas in our clinic in the past 10 years from Jan. 2004 to Dec. 2013. The tumors were located in the head (n = 10), trunk (n = 9), limbs (n = 5), and multi-sites (n = 2). According to the locatio...

Guggulsterone (GUG), a resin of the Commiphora mukul tree, has been used in ayurvedic medicine for centuries to treat a variety of ailments. Recent studies have suggested that GUG may also possess anticancer effects. In the present study, we show that GUG possesses antitumor-promoting effects in SENCAR mouse skin tumorigenesis model. We first determined the effect of topical application of GUG ...

This study investigates the optimal external parameters for using an ultrasound applicator for treating bone tumors. This system utilized spherically arranged applicators such as scanned focused ultrasound, and spherically focused multielement applicators. The power deposition pattern is modeled as geometric gain with exponential attenuation. The specific absorption rate ratio (SARR) criteria h...

(+)-Camptothecin (CPT), a topoisomerase I inhibitor specifically toxic toward S phase cells, was tested topically for its ability to inhibit skin tumor initiation by 7,12-dimethylbenz[a]anthracene (DMBA) and complete tumor promotion by 12-0-tetradecanoylphorbol-13-acetate (TPA) in SENCAR mice. Even though CPT does not prevent the covalent binding of a subcarcinogenic dose of DMBA to DNA, it enh...

Our laboratory has been studying cancer chemopreventive effects of polyphenolic fraction isolated from green tea (GTP). In prior studies we have shown that (a) GTP possesses antigenotoxic effects in various test systems; (b) topical application of GTP protects against UV radiation and chemical carcinogen-induced tumorigenesis in murine skin; and (c) feeding of GTP in drinking water p.o. to mice...

Kutanöz lenfadenom, trikoblastomun adamantoid varyantı olarak sınıflandırılan benign adneksiyal bir deri tümörüdür. Nadir görülmekte olup ayırıcı tanıda derinin sık görülen tümörü bazal hücreli karsinom ile karışmaktadır. Patologlar için akılda tutulması gereken, karışan, nadir eki tümörünün histopatolojik ve immünohistokimyasal bulgularını sunduk.

Background: Topical application of 1a, 25-dihydroxyvitamin D3 (1-a,25-(OH)2D3) inhibits7, 12-dimethylbenz [a] anthracene (DMBA) and 12-a-tetradecanoylphorbol-13-acetate (TPA)-induced tumor formation of mouse skin. Ultraviolet irradiation (UV) may also induce skin tumors. However, no report exists regarding the effect of topical active vitamin D3, tacrolimus, or corticosteroids on UV-irradiation...