Treatment of post burn contractures of the hand, implies in most of cases the use of a full thickness skin graft, especially when the contracture doesn’t involve deeper structures but only the skin and the subcutaneous tissues. But in spite of being the “golden standard” in the treatment of these cases, use of a full thickness skin graft carries with it certain inconveniences such as those rela...

An adult female patient with primary lymphedema of the lower extremity was treated with total excision of the subcutaneous tissues followed by delayed reconstruction with a giant full thickness skin graft taken from the excised surgical specimen. The leg has maintained excellent function and contour over the ensuing 15 years. A small area on the dorsum of the foot that initially was covered wit...

Full thickness skin and soft tissue losses secondary to traumatic and war-related injuries remain a challenge for reconstructive surgeons. Strategies to restore skin barrier functions while also being durable and possessing appropriate pigmentation are of interest. Herein, the outcomes, function and appearance of a restorative skin strategy employing a dermal regenerate template with a spray-on...

Diabetic foot ulcerations are historically difficult to treat despite advanced therapeutic modalities. There are numerous modalities described in the literature ranging from noninvasive topical wound care to more invasive surgical procedures such as primary closure, skin flaps, and skin grafting. While skin grafting provides faster time to closure with a single treatment compared to traditional...

A Large scale of full-thickness skin defects is lack of auto-grafts and which requires the engineered skin substitutes for repair and regeneration. One major obstacle in skin tissue engineering is to expand epidermal stem cells (ESCs) and develop functional substitutes. The other one is the scaffold of the ESCs. Here, we applied type I collagen-modified chitin membrane to form collagen-chitin b...

We developed the novel silk fibroin-based bilayered wound dressing for the treatment of partial thickness wounds. And it showed relevant characteristics and accelerated the healing of full-thickness wounds in a rat model. This study is the clinical evaluation of the bilayered wound dressing to confirm its safety and efficacy for the treatment of split-thickness skin donor sites. The safety test...