OBJECTIVE Isocyanates (di- and poly-), important chemicals used worldwide to produce polyurethane products, are a leading cause of occupational asthma. Respiratory exposures have been reduced through improved hygiene controls and the use of less-volatile isocyanates. Yet isocyanate asthma continues to occur, not uncommonly in settings with minimal inhalation exposure but opportunity for skin ex...

240 Mold Sensitization in Chronic Rhinosinusitis Patients Radoslaw Gawlik, MD, PhD, and Eugeniusz Czecior, MD, PhD. Internal Medicine, Allergy and Clin Immunology, Silesian University of Medicine, Katowice, Poland; Silesian University of Medicine, Zabrze, Poland. Background: It is estimated that about 10% of the population have IgE antibodies to common inhalant molds. Exposure to fungal allerge...

240 Mold Sensitization in Chronic Rhinosinusitis Patients Radoslaw Gawlik, MD, PhD, and Eugeniusz Czecior, MD, PhD. Internal Medicine, Allergy and Clin Immunology, Silesian University of Medicine, Katowice, Poland; Silesian University of Medicine, Zabrze, Poland. Background: It is estimated that about 10% of the population have IgE antibodies to common inhalant molds. Exposure to fungal allerge...

62 Keratinocytic Thymic Stromal Lymphopoietin Plays an Important Role in Epicutaneous Sensitization and the Atopic March Juan Manuel Leyva Castillo, MSc, Pierre Hener, Hua Jiang, PhD, Daniel Metzger, PhD, Pierre Chambon, PhD, and Mei Li, PhD. Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS UMR-7104/INSERM U964/UdS, Illkirch CEDEX, France. Bac...

Allergic contact dermatitis (ACD) is one of the most common inflammatory skin diseases, which is classified as a delayed-type hypersensitivity immune response. The development of ACD is divided into two phases: sensitization and elicitation. In the sensitization phase, antigen-specific effector T cells are induced in the draining lymph nodes by antigen-captured cutaneous dendritic cells (DCs) t...

METHODS. Subjects were designated as having mild, moderate, or severe AD based on SCORing Atopic Dermatitis index. Skin prick testing and specific immunoglobulin E testing to foods and aeroallergens allergens were used to determine allergic sensitization. Peripheral eosinophil counts, 25-hydroxy vitamin D levels, and total immunoglobulin E were measured. Patients were grouped according to aller...

Atopic dermatitis can be due to a variety of causes from nonatopic triggers to food allergy. Control of egress of water and protection from ingress of irritants and allergens are key components of cutaneous barrier function. Current research suggests that a degraded barrier function of the skin allows the immune system inappropriate access to environmental allergens. Epidermal aeroallergen expo...