Heat strain in chemical protective clothing is an important factor in industrial and military practice. Various improvements to the clothing to alleviate strain while maintaining protection have been attempted. More recently, selectively permeable membranes have been introduced to improve protection, but questions are raised regarding their effect on heat strain. In this paper the use of select...

the aim of the present study was to investigate the relationship between the polar surface area and other molecular properties of the model drugs and their transdermal permeability across the rat skin. few model drugs which are weakly acidic (ibuprofen, aceclofenac and glipizide) and weakly basic (olanzapine, telmisartan and sildenafil citrate) were selected for the study based on polar surface...

The delivery of medications through the skin has long been a fascinating as well difficult subject study. For different medications, topical drug administration brought substantial benefits over systemic route, one most important which is reduced toxicity due to minimal or no exposure non-target organs. Because its simplicity and affordability, preferred method for delivering medicinal substanc...

nowadays use of edible films and coatings is increasing due to their biodegradability properties. fish gelatin obtained from fish skin wastage can be used as an appropriate protein compound for preparation of edible films and replacing pork gelatin. in this study, films were prepared from a combination of fish gelatin and three phenolic compounds (caffeic acid, tannic acid and ferulic acid) at ...

The transdermal delivery system of nutrients, cosmetics, and drugs is particularly attractive for painless, noninvasive sustainable release. Recently, atmospheric pressure plasma techniques have been great interest to improve the drug absorption rate in delivery. Currently, plasma-mediated changes lipid composition stratum corneum are considered a possible mechanism increase permeability. Never...

A reservoir type transdermal patch for delivery of ketorolac, a potent analgesic agent was studied. The low permeability of skin is the rate-limiting step for delivery of most of the drugs. Studies were carried out to investigate the effect of permeation enhancers on the in vitro permeation of ketorolac across rat skin. The reservoir type transdermal patch was fabricated and the core was filled...

The technology of fabricating microneedle arrays to deliver high molecular weight drugs across skin in a minimally invasive manner is receiving increasing attention. Microneedle arrays with different geometries have been manufactured using materials such as glass, polymer, metal, etc. However, a framework that can identify the optimum designs of these arrays seems to be lacking. This is importa...