Given its advantages in skin application (eg, hydration, antiaging, and protection), argan oil could be used in both dermatological and cosmetic formulations. Therefore, the preparation of nanostructured lipid carriers (NLCs) using argan oil as a liquid lipid is a promising technique, since the former constitute well-established systems for dermal delivery. The aim of this work was to develop a...

In a novel application of dual-channel high-speed two-photon fluorescence microscopy, the skin autofluores-cence and the transdermal fluorescent model drug spatial distributions were imaged simultaneously over precisely the same spatial coordinates. The dual channels enable the detection of the fluorescence emission wavelengths characteristic of the endogenous (intrinsic) skin fluorophores, as ...

The electron spin resonance (ESR) spectra of alkyl spin labels were observed in the excised guinea pig dorsal skin, its stratum corneum, delipidized skin and stratum corneum model lipid liposomes. The spectrum of 5-doxylstearic acid (5-NS) in the stratum corneum and order parameter obtained from the spectrum, indicated that the spin label was present in highly ordered lipid lamella. On the othe...

Among the various functions of skin, epidermal barrier plays a key role in protecting body from excessive water loss and entry exogenous substances. One essential components permeability is extracellular lipid matrix stratum corneum. The mainly composed ceramides, cholesterol fatty acids. these lipids, ceramides are critical to maintain function skin. main enzyme responsible for conversion gluc...

Background: Lichen planus (LP) is a chronic inflammatory disease involving the skin, mucous membranes and appendages. Like other chronic inflammatory diseases, it may be associated with metabolic disorders and dyslipidemia. Due to the discrepancies in the results of previous studies and lack of a similar study on an Iranian population, we decided to investigate and compare the serum lipid...

Epidermal growth factor (EGF) acts as a paracrine and autocrine mediator of cell proliferation differentiation in various types epithelial cells, such sebocytes, which produce the lipid-rich sebum to moisturize skin. However, lipids via direct contact by penetrating through epidermis may have regulatory roles on epidermal dermal cells well. As EGF receptor (EGFR) is expressed throughout prolife...

While most T cells recognize peptide antigens presented by major histocompatibility complex (MHC) class I and class II molecules, some T cells react with lipid antigens presented by MHC-related CD1 proteins. In this issue, Bourgeois et al. establish the concept that enzymes in bee venom can cleave host skin-derived phospho-lipids into lipid neoantigens that activate CD1a-restricted T cells to p...