Methods for handling burn wounds have changed in recent decades. Increasingly, aggressive surgical approach with early tangential excision and wound closure is being applied leading to improvement in mortality rates of burn victims. Autografts from uninjured skin remain the mainstay of treatment. Autologous skin graft, however, has limited availability and is associated with additional morbidit...

INTRODUCTION To investigate the effect of subcutaneous fat suture closure versus non-closure at cesarean section (CS) on long-term cosmetic outcome. MATERIAL AND METHODS Women undergoing planned or unplanned CS were randomized to either subcutaneous fat suture closure or non-closure using a 1∶1 allocation algorithm. Participants and outcome assessors were blinded to group allocation. Scar eva...

BACKGROUND The efficacy of negative-pressure wound therapy as a bridge to definitive closure of traumatic extremity wounds has been demonstrated in adults. Gauze-based negative-pressure wound therapy has been used to facilitate granulation tissue formation and promote closure in a number of wound types. In this study, the authors evaluated the efficacy of gauze-based negative-pressure wound the...

Figure 1. Patient presenting at age 6 after several surgical attempts at closure. She has unstable skin graft over allogenic dermis graft. A 6-year-old girl had undergone multiple operations for an omphalocele but still retains a very large ventral hernia. She presented with an eventrated abdomen with unstable, scarred closure (see Fig. 1). A reconstruction using intermuscular tissue expanders ...

Pilonidal sinus disease (PSD) is a common chronic, benign disease of young adulthood. Pilonidal disease is an infection under the skin in the gluteal cleft. Pilonidal literally means a „„nest of hair”. Known risk factors include family history, local trauma, sedentary occupation, and obesity. Pilonidal sinus disease is a blind track, which extends from the skin of natal cleft up to the presacra...

Advanced glycoxidation end products (AGEs) are implicated in delayed diabetic wound healing. To test the role of diet-derived AGE on the rate of wound healing, we placed female db/db (+/+) (n = 55, 12 weeks old) and age-matched control db/db (+/-) mice (n = 45) on two diets that differed only in AGE content (high [H-AGE] versus low [L-AGE] ratio, 5:1) for 3 months. Full-thickness skin wounds (1...

The aim of this study was to determine the local and systemic effects of adipose-derived stem cells (ADSCs) as a component of topical skin adhesive in an animal artificial wound closure model. In presented study the cosmetic effects, histological analysis, mechanical properties, and cell migration have been assessed to evaluate the usefulness of ADSCs as supporting factor for octyl blend cyanoa...

OBJECTIVE To show the results and advantages of using the negative pressure closure system in a pediatric population with infections and wound closure defects. MATERIAL AND METHODS A retrospective analysis was conducted on pediatric patients in whom the VAC(®) negative pressure wound closure system was used in the Shriners Hospital for Children, Mexico, from January 2008 to December 2012. We ...