Transient receptor potential (TRP) channels constitute a somewhat eclectic family of ion channels that share structural similarities and some functional properties, especially cation permeability and weak voltage sensitivity. TRP channels are expressed in virtually every cell type present in the heart, including cardiomyocytes, fibroblasts, endothelial cells and vascular smooth muscle cells. In...

The glomerular filtration barrier is made up of fenestrated endothelium, the endothelial surface layer, glomerular basement membrane, and podocytes forming a slit diaphragm between interdigitating foot processes and the subpodocyte space.1 Disruption of the filtration barrier results in loss of permselectivity and macromolecules such as albumin in urine. There is evidence to support the relativ...

Insulin is an essential hormone for the control of blood glucose level and glucose metabolism. Additionally, insulin mediates a wide spectrum of biological responses including lipid metabolism, protein synthesis, activation of transcription of specific genes, modulation of cellular growth and differentiation, and functional regulation of ion channels and transporters in various types of cells. ...

As the sole Ca entry mechanism in a variety of non-excitable cells, store-operated calcium (SOC) influx is important in Ca signalling andmany other cellular processes. A calcium-releaseactivated calcium (CRAC) channel in T lymphocytes is the bestcharacterized SOC influx channel and is essential to the immune response, sustained activity of CRAC channels being required for gene expression and pr...

The TRP superfamily of channels (nomenclature as agreed by NC-IUPHAR [176, 1072]), whose founder member is the Drosophila Trp channel, exists in mammals six families; TRPC, TRPM, TRPV, TRPA, TRPP and TRPML based on amino acid homologies. subunits contain putative TM domains assemble homo- or hetero-tetramers to form cation selective with diverse modes activation varied permeation properties (re...

In addition to the classical nuclear receptor pathway, there is a non-genomic pathway in the cell membrane that regulates gene expression in animal steroid hormone signaling; however, this mechanism is unclear. Here, we report that the insect steroid hormone 20-hydroxyecdysone (20E) regulates calcium influx via phospholipase C gamma 1 (PLCG1) to modulate the protein kinase C (PKC) phosphorylati...