In mice, induced global disruption of the Ptpn11 gene, which encodes the SHP-2 tyrosine phosphatase, results in severe skeletal abnormalities. To understand the extent to which skeletal abnormalities can be attributed to perturbation of SHP-2 function in bone-forming osteoblasts and chondrocytes, we generated mice in which disruption of Ptpn11 is restricted to mesenchymal stem cells (MSCs) and ...

FHL1 is multifunctional and serves as a modular protein binding interface to mediate protein-protein interactions. In skeletal muscle, FHL1 is involved in sarcomere assembly, differentiation, growth, and biomechanical stress. Muscle abnormalities may play a major role in congenital clubfoot (CCF) deformity during fetal development. Thus, identifying the interactions of FHL1 could provide import...

PURPOSE Percutaneous epiphysiodesis using transphyseal screws (PETS) was developed as a minimally invasive outpatient procedure to address limb-length discrepancy (LLD) that allowed immediate postoperative weight bearing and was potentially reversible by removing the screws. The aims of our study were to report our results using PETS for LLD and evaluate the accuracy of three growth predictor m...

BACKGROUND The precise etiology of cam impingement continues to be incompletely understood. The prevailing hypothesis posits that the deformity arises as a developmental injury prior to skeletal maturation. There is a possible evolutionary role, with an aspherical femoral head affording upright humans better stability. We set out to identify the antiquity of the cam deformity to better understa...

Abstract Introduction Idiopathic scoliosis, defined as a > 10° curvature of the spine in frontal plane, is one most common spinal deformities. Age, initial curve magnitude and other parameters define whether scoliotic deformity will progress or not. Still, their interactions amounts individual contribution are not fully elaborated were aim this systematic review. Methods A literature search ...

Classic homocystinuria is a rare autosomal recessive disorder of methionine metabolism resulting from deificiency cystathionine beta-synthase that involved in transsulfuration homocysteine. The caused by mutations CBS gene. Lack enzyme associated with accumulation homocysteine induce various toxicities, e.g. endothelial dysfunction and increased risk thrombosis. Clinical manifestations classic ...

OBJECTIVE The displacement of the hyoid bone (HB) is a critical biomechanical component of the swallowing function. The aim of this study was to evaluate the swallowing-induced vertical and horizontal displacements of the HB in subjects with 2 different magnitudes of skeletal Class III malocclusion, by means of real-time, balanced turbo-field-echo (B-TFE) cine-magnetic resonance imaging. METH...

The maxillofacial region of patients with facial asymmetry is deformed not only in the mandible but also maxilla, suggesting that head may be deformed. Therefore, this study, skeletally originated mandibular prognathism was evaluated relation to cranial morphology. morphology who visited Chiba Dental Center Tokyo College and were diagnosed skeletal (asymmetry group: ANB 0° or less; Menton devia...