Recent grid-based document representations like BERTgrid allow the simultaneous encoding of textual and layout information a in 2D feature map so that state-of-the-art image segmentation and/or object detection models can be straightforwardly leveraged to extract key from documents. However, such methods have not achieved comparable performance sequence- graph-based as LayoutLM PICK yet. In thi...

Niemann-Pick type C disease is a rare and ultimately fatal lysosomal storage disorder with variable neurologic symptoms. The disease-causing mutations concern NPC1 or NPC2, whose dysfunction entails accumulation of cholesterol in the endosomal-lysosomal system and the selective death of specific neurons, namely cerebellar Purkinje cells. Here, we investigated whether neurodegeneration is preced...

We present a binomial approach for pricing contingent claims when the parameters governing the underlying asset process follow a regime-switching model. In each regime, the asset dynamics is discretized by a Cox-Ross-Rubinstein lattice derived by a simple transformation of the parameters characterizing the highest volatility tree, which allows a simultaneous representation of the asset value in...

In this paper we demonstrate coordinated control of multiple micromanipulators for use in automated 3D micromanipulation and assembly tasks. We build on our previous work on caging micromanipulation by using a similar methodology and extend it to the 3D case. Simultaneous movements of the coordinated micromanipulators normal to the caging polygon allows for the transition of 2D planar micro-cag...

The vehicle routing problem with simultaneous pickup and delivery (VRPSDP) is a common transportation problem where a fleet of vehicles deliver goods from the depot to line haul customers and pick up goods from backhaul customers to the depot. This problem variation allows vehicles to make the delivery and pickup operations on same time by visiting all clients once with the aim of minimization ...

S U M M A R Y Locating earthquakes from the beginning of the modern instrumental period is complicated by the fact that there are few good-quality seismograms and what traveltimes do exist may be corrupted by both large phase-pick errors and clock errors. Here, we outline a Bayesian approach to simultaneous inference of not only the hypocentre location but also the clock errors at each station ...

Article history: Received 6 April, 2015 Accepted 10 October 2015 Available online 11 October 2015 This article provides a method of acoustic emission (AE) technique to detect leakage in pipeline and locate the position of the leakage. The AE sensor is made of piezoelectric effect transducer to pick up the acoustic emission signal which is generated from the turbulent flow at the leak position. ...

This paper uses classical logic for a simultaneous description of the syntax and semantics of a fragment of English and it is argued that such an approach to natural language allows procedural aspects of linguistic theory to get a purely declarative formulation. In particular, it will be shown how certain construction rules in Discourse Representation Theory, such as the rule that indefinites c...

Export of LDL-derived cholesterol from lysosomes requires the cooperation of the integral membrane protein Niemann-Pick C1 (NPC1) and a soluble protein, Niemann-Pick C2 (NPC2). Mutations in the genes encoding these proteins lead to Niemann-Pick disease type C (NPC). NPC2 binds to NPC1's second (middle), lumenally oriented domain (MLD) and transfers cholesterol to NPC1's N-terminal domain (NTD)....

Adhesion between the oocyte-cumulus complex and infundibulum plays an important, but poorly understood, role in oocyte pick-up. The purposes of this study were to determine which components of the oocyte-cumulus complex and oviductal epithelium function in adhesion, to measure adhesion under physiological conditions, and to examine the effect of modulation of adhesion on oocyte-cumulus complex ...