Silicosis is a form of occupational lung disease caused by inhalation of crystalline silica dust. While the pathogenesis of silicosis is not clearly understood, the Wnt/β-catenin signaling pathway is thought to play a major role in lung fibrosis. To explore the role of Wnt/β-catenin pathway in silicosis, we blocked Wnt/β-catenin pathway both in silica-treated MLE-12 cells (a mouse pulmonary epi...

The improvement of social support promotes the mental health and improves the health status. The study aimed to examine the influence of the social support on symptoms of anxiety and depression among patients with silicosis and provide the scientific basis to further alleviate anxiety and depression and to monitor their whole quality of life. We investigated 324 inpatients with silicosis betwee...

background: agate is a hard silica stone with bands of various colors, which is used in jewelry. the agate grinding workers are exposed to silica dust. objective: to determine the prevalence of respiratory diseases in agate grinding workers and the associated factors. methods: in this cross-sectional study, 170 agate grinding workers from mashhad, northeastern iran, were examined. medical and o...

BACKGROUND Silicosis is an occupational lung disease caused by inhalation of silica dust characterized by lung inflammation and fibrosis. Previous study showed that Th1 and Th2 cytokines are involved in silicosis, but Th1/Th2 polarization during the development of silicosis is still a matter of debate. Regulatory T cells (Treg cells) represent a crucial role in modulation of immune homeostasis ...

Smokers are subject to being more susceptible to the long-term effects of silica dust, whilst it remains unclear whether the joint effect of smoking and silicosis differs amongst diseases to the lungs; this study aims to address this knowledge gap. This was a historical cohort study comprised of 3202 silicotics in Hong Kong during 1981-2005 who were followed up till 31/12/2006. We estimated the...

The claim of Denny and others (1937; 1939) to have prevented silicosis in quartz-dusted animals by the simultaneous administration of aluminium was not substantiated in the experiments of Belt and King (1943) and of King and others (1945), using the intratracheal injection technique of Kettle and Hilton (1932). But it was pointed out by King (1947), in similar experiments, that the aluminium mi...

Abstract:
 The diagnosis of Silicosis Disease is based on regular follow-up, including physical examination, anamnesis and imaging methods, chest radiography high resolution computed tomography (HRCT) which are the main modalities shaped by universal guidelines. Due to its advantages such as rapid results, non-invasiveness, less cost procedure radiation safety, thoracic ultrasound an metho...

To examine risk for mycosis among persons with silicosis, we examined US mortality data for 1979-2004. Persons with silicosis were more likely to die with pulmonary mycosis than were those without pneumoconiosis or those with more common pneumoconioses. Health professionals should consider enhanced risk for mycosis for silica-exposed patients.

The heart and the respiratory system are closely connected in such a way that disorders of one system would influence the function of the other. This unique case of silicosis complicated by corpulmonale associated with pericardial plaque formation in a young adult male is reported here due to an unknown complication of silicosis.