We have investigated in vitro the release kinetics and bioactivity of fibroblast growth factor-2 (FGF-2) released from a carrier of fibrin sealant. In order to evaluate the effects of the FGF-2 delivery mechanism on the repair of articular cartilage, full-thickness cylindrical defects, 5 mm in diameter and 4 mm in depth, which were too large to undergo spontaneous repair, were created in the fe...

BACKGROUND Epidural hematomas, cerebrospinal fluid fistula, and spinal infections are challenging postoperative complications following vertebro-spinal procedures. We report our preliminary results using autologous fibrin sealant as both fibrin glue and a hemostatic during these operations. METHODS Prospectively, between January 2013 and March 2015, 68 patients received an autologous fibrin s...

We analyzed the cost-effectiveness of 3 sealant delivery strategies: Seal all (SA), seal children assessed to be at risk by screening (TARGET), and seal none (SN). We assumed a nine-year analytic horizon, a 3% discount rate, and zero screening costs. Estimates for sealant costs ($27.00) and restoration costs ($73.77), annual caries increment (0.0624 surfaces), sealant failure rate (20% in yr 1 ...

BACKGROUND The use of CoSeal(®), a polyethylene glycol sealant, in cardiac and vascular surgery for prevention of anastomotic bleeding has been subject to prior investigations. We analysed our perioperative data to determine the clinical benefit of using polyethylene glycol sealant to inhibit suture line bleeding in aortic surgery. METHODS From January 2004 to June 2006, 124 patients underwen...

F or adequate sealant retention, the bonding surface area must be maximized and the enamel clean, free of salivary contamination, and dry at the time of sealant placement.I, 2 However, because pit and fissure sealants bond to the cuspal incline planes and not to the bottoms of the pits and fissures,B_6 insufficient curing of the resin sealant could reduce the bond strength. The purpose of this ...

objective: the aim of this study was to evaluate the efficacy of enamel bonding agents on pit and fissure sealant retention in a well-isolated situation. materials and methods: thirty-two patients (6-9 years old, all males) with four fully erupted permanent first molars were selected. their occlusal, buccal, and lingual fissures were sealed according to a split-mouth design using concise light ...

AIM To evaluate the effects of two different resin coating materials on the clinical performance of a conventional glass ionomer sealant. MATERIALS AND METHODS Permanent first mandibular molars of 60 children aged 6-9 years were sealed with Fuji VII. In each child, G-Coat Plus coating agent was applied to molars on one side and Heliobond coating agent to molars on the opposite side of the mou...

Study Design Case report. Objective Incidental durotomy (IDT) is a common complication of spinal surgery. The use of collagen matrix graft along with hydrogel dural sealant is a common method of IDT repair. With this method, there have been several reported cases of detrimental dural sealant expansion in the literature. One case study reported an expansion rate greater than 300%; many report ne...