Targeting genes in disease has long been a sought-after holy grail, with the concept of gene therapy promising a magic bullet for single gene mutation or deletion disorders. Replacing deficient or non-functional genes with the active form has proven more difficult to achieve than originally hoped. However, a subset of gene therapy termed ‘gene silencing’ is being developed, which is altogether ...

Since fear of silence is a striking feature of stuttering, this study investigated the effect of experimentally imposed silence. 24 adult stutterers read 4 passages aloud, S times each, under 3 conditions of imposed silence (introduced following the 2nd reading), and under 1 control condition. They then ranked these situations as to their evoked discomfort. Unexplained Silence, Explained Silenc...

Purpose The aim of this study is to explore and unpack the notion lateral voice within context a Chinese hospital. Design/methodology/approach A qualitative design was used, involving interviews 24 medical personnel from public hospital in mainland China. This included two focus groups (eight participants each) physicians nurses, eight individual with managers, including chief nurse directors c...

background: individuals, who spend most of their time sitting, are at 30% more risk of suffering from lumbar disc than other people. one of the causes of pain in the lumbar region is musculoskeletal disorders (msds). msds are the most common and most costly injuries in occupational, administrative, and academic environments. therefore, the aim of this study was to investigate the relationship b...

OBJECTIVE The purpose of this study was to examine the effect of optimal seated positioning in individually fitted furniture versus suboptimal seated positioning in standard classroom furniture on typical 6- and 7-year-old children's object manipulation skills as measured by the In-hand Manipulation Test (IMT). METHOD An experimental research design was used to compare IMT performance of two ...

This chapter explores the poetics of everyday objects, and their abilities to elicit meaningful interactions. Our focus is on a special kind of everyday objects: a chosen set of “augmented” chairs and tables, especially designed to gently disrupt usually associated emotional / social responses, and shake habitual ways in which people interact with – and through – furniture. We address the physi...