BACKGROUND Sickle cell disease (SCD) affects the kidney by acute mechanisms as well as by insidious renal medullary/papillary necrosis, resulting in tubular defects, which increase the risk of dehydration and subsequent sickle crisis. Hypoxia has been reported to stimulate endothelin-1 (ET-1) synthesis by endothelial cells and also in the renal tubule. METHODS This case-control study measured...

Sickle cell nephropathy (SCN) is associated with iron/heme deposition in proximal renal tubules and related acute tubular injury (ATI). Here we report the utility of iron staining in differentiating causes of renal allograft dysfunction in patients with a history of sickle cell disease. Case 1: the patient developed acute allograft dysfunction two years after renal transplant. Her renal biopsy ...

background: the vascular response to recurrent tissue hypoxia and reperfusion following red blood cell sickling causes acute chest syndrome and chronic lung disease. the purpose of this study was to determine the pattern of chronic lung lesions and possible risk factors in sickle cell patients in lagos, nigeria.methods: from july 2012 to april 2013, pulmonary function test (pft) and chest-x-ray...

background although it is life-saving, blood transfusion therapy has resulted in risk for transfusion-transmitted infections (ttis) in the majority of sickle cell anemia being patients. objectives the current study aimed to determine the prevalence of hbv, hcv and different genotypes of hcv among sickle cell anemia (sca) patients in ahvaz city, south-western iran. materials and methods a cross-...

Sickle cell disease is an autosomal recessive hematological disorder resulting from a missense point mutation in the beta chain of haemoglobin molecule. This article reports case homozygous sickle adult patient with long-standing history non-healing ulcer

background sickle hemoglobin is the most common abnormal hemoglobin in the united states. hemoglobin s arises as a result of a single amino acid substitution (glutamic acid to valin at position 6 of the β-globine chain). the presence of fetal hemoglobin (hbf) plays a relatively protective role since a significant amount of hbf interferes with hbs polymerization, the pathogenesis mechanism of th...

Bone marrow transplantation is the only cure for sickle cell disease but this curative therapy unfortunately lead to complication and several times death. indicated patients with severe who have complications including strokes, acute chest syndrome, recurrent pain crisis exchange transfusions, nephropathy retinopathy, osteonecrosis of multiple joints priapism. All are not eligible bone due asso...