The aim of this study was to determine hematological profile of sickle cell disease (SCD) from Surat, South Gujarat, India. This prospective cross-sectional study was conducted in the Department of Pediatrics and Sickle Cell Anemia Laboratory, Faculty of Pathology, Government Medical College, Surat, India, between July 2009 and December 2010. Patients included in this study were in their steady...

The article examines medical and scientific studies of sickle cell anemia published in Brazil in the 1930s and 1940s, when the vast majority of physicians and scientists believed that miscegenation played a significant role in the epidemiology of the disease in the country. Special focus is placed on hematologist Ernani Martins da Silva, of the Oswaldo Cruz Institute, who conducted blood analys...

Hemodynamic studies in 13 unselected patients with sickle cell anemia are reported. Twelve of these patients were also studied during mild exercise. The cardiac output at rest was elevated in all and rose significantly with exercise in 9 of the 12 patients. The importance of the increased percentage extraction of oxygen by the tissues in modifying the response of the cardiac output is discussed...

We have determined the frequency of deletional a-thalassemia in black populations in the USA and Africa that harbor sickle cell anemia. In normals. the frequency of the chromosome bearing a deletion of one of the two normal a gene loci. designated ( -a). ranged from 0.12 to 0.16, and in sickle trait subjects. the frequency ranged from 0.1 8 to 0.20. By contrast. in sickle cell anemia subjects. ...

In 1949, Linus Pauling and his collaborators published a study in the journal Science entitled "Sickle Cell Anemia, a Molecular Disease." In this now classic study, they showed that hemoglobin from patients suffering from sickle cell anemia has a different electrical charge than hemoglobin from healthy individuals. This result demonstrated for the first time that an abnormal protein could be ca...

By SAMUEL CIIARAcIIE AND C. LOCKARD CONLEY S ICKLED ERYTHROCYTES are rapidly removed for the circulation, an occurrence that accounts for the hemolytic aspects of sickle cell disease.’ Anemia is a usual result but is often asymptomatic and is not the principal cause of the high morbidity and reduced life span of affected persons. Many of the clinical manifestations of sicklemia have been attrib...