Chronic low-grade inflammation contributes to the pathology and complications of type 2 diabetes (T2D). Interleukin-10 (IL10), an anti-inflammatory cytokine, is suggested to play a protective role in T2D. However, the impact of T2D on IL10 function has not been previously assessed. We examined the ability of IL10 to inhibit inflammation in human T2D immune cells and explored underlying mechanis...

Abstract Colorectal cancer (CRC) is the 2 nddeadliest globally and has 3 rdhighest incidence mortality in United States. Advanced-stage disease incurable by current clinical standards. Thus, alternative treatments are being explored, including immune checkpoint blockade (ICB) to prevent T cell inactivation tumors. ICB induces a robust response patients with microsatellite instability-high (MSI-...