نتایج جستجو برای: ship dismantling zone

تعداد نتایج: 128716  

Journal: :The Journal of Cell Biology 2001
Jennifer M. Dyson Cindy J. O'Malley Jelena Becanovic Adam D. Munday Michael C. Berndt Imogen D. Coghill Harshal H. Nandurkar Lisa M. Ooms Christina A. Mitchell

SHIP-2 is a phosphoinositidylinositol 3,4,5 trisphosphate (PtdIns[3,4,5]P3) 5-phosphatase that contains an NH2-terminal SH2 domain, a central 5-phosphatase domain, and a COOH-terminal proline-rich domain. SHIP-2 negatively regulates insulin signaling. In unstimulated cells, SHIP-2 localized in a perinuclear cytosolic distribution and at the leading edge of the cell. Endogenous and recombinant S...

Journal: :The Journal of Experimental Medicine 2001
Dianne Cox Benjamin M. Dale Masaki Kashiwada Cheryl D. Helgason Steven Greenberg

The Src homology 2 domain-containing inositol 5'-phosphatase (SHIP) is recruited to immunoreceptor tyrosine-based inhibition motif (ITIM)-containing proteins, thereby suppressing phosphatidylinositol 3-kinase (PI 3-kinase)-dependent pathways. The role of SHIP in phagocytosis, a PI 3-kinase-dependent pathway, is unknown. Overexpression of SHIP in macrophages led to an inhibition of phagocytosis ...

Journal: :Blood 1999
D M Lucas L R Rohrschneider

SH2-containing Inositol Phosphatase (SHIP) is a 145 kD protein expressed in hematopoietic cells. SHIP is phosphorylated on tyrosine after receptor binding by several cytokines and has a negative role in hematopoiesis. We cloned a murine complementary DNA (cDNA) sequence for an isoform of SHIP with an internal 183 nucleotide deletion, encoding a protein 61 amino acids shorter than 145 kD SHIP. T...

Journal: :Canadian Medical Association Journal 2015

Journal: :IACR Transactions on Cryptographic Hardware and Embedded Systems 2018

2011
Payal Mehta Anne-Sophie Wavreille Steven E. Justiniano Rachel L. Marsh Jianhua Yu Richard W. Burry David Jarjoura Timothy Eubank Michael A. Caligiuri Jonathan P. Butchar Susheela Tridandapani

SHIP and SHIP-2 are inositol phosphatases that regulate FcγR-mediated phagocytosis through catalytic as well as non-catalytic mechanisms. In this study we have used two-dimensional fluorescence difference gel electrophoresis (DIGE) analysis to identify downstream signaling proteins that uniquely associate with SHIP or SHIP-2 upon FcγR clustering in human monocytes. We identified LyGDI as a bind...

2014
Mary Munson

A protein known for its role in dismantling faulty SNARE complexes can also help to maintain complexes that have formed properly during membrane fusion.

Journal: :The Journal of Experimental Medicine 1998
Qiurong Liu Antonio J. Oliveira-Dos-Santos Sanjeev Mariathasan Denis Bouchard Jamie Jones Renu Sarao Ivona Kozieradzki Pamela S. Ohashi Josef M. Penninger Daniel J. Dumont

Ship is an Src homology 2 domain containing inositol polyphosphate 5-phosphatase which has been implicated as an important signaling molecule in hematopoietic cells. In B cells, Ship becomes associated with Fcgamma receptor IIB (FcgammaRIIB), a low affinity receptor for the Fc portion of immunoglobulin (Ig)G, and is rapidly tyrosine phosphorylated upon B cell antigen receptor (BCR)-FcgammaRIIB ...

1999
J. Zhang

Field infiltration tests were conducted at a hillside near the ship lock of the Three Gorges Dam in Hubei Province, China. The test site consists of residual soil and decomposed granite. The infiltration rate is estimated from the in situ tests to be 1.465–2.778×10−6 m s−1, depending on the initial water content. The rate at which the infiltration front moves down through the soil matrix within...

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