Compelling evidences from transgenic mice, immunoprecipitation data, gene expression analysis, and functional heterologous expression studies supported the role of Kv channel interacting proteins (KChIPs) as modulators of Kv4 (Shal) channels underlying the cardiac transient outward current and neuronal A-type current. Till now, there are four members (KChIP1-4) identified in this family. KChIP1...

in this study genetic diversity of eight iranian sheep breeds including; lori bakhtiari, makuei, moghani, taleshi, shal, zandi, naeini and kalakui was studied by using aflp method. a total of 309 individuals were analysed that produced 121 clear polymorphic bands. the average of heterozygosity within breed (hs) was high and equal to 0.2795± 0.0255. also, the average heterozygosity between breed...

this experiment was conducted to improve the nutritive value of barley stubble for two consecutive years. after harvesting crop, at first year, a completely randomized design, with a 3 × 3 factorial experiment was conducted in which 27 plots were divided into nine treatments. the treatments including zero, 2.5 and five percent urea each with zero, three and six percent molasses were mixed with ...

Background & Aim:A new sustainable tissue-based system is presented by plant hairy roots, preserving all of the several specialized types of cell with critical roles in allowing bioactive secondary molecules to be synthesized more consistently as usual. The system is also essential for studying the production of alkaloid in culture. Experimental: The ...

Objectives- To isolate, culture-expand and differentiate mesenchymal stem cells from ovine bone marrow and determine their culture requirements for high expansion rate. Design- Experimental study. Animals- Five Shal sheep. Procedures- In this study, ovine marrow cells were plated and culture expanded through 3 successive subcultures. The resultant cells were then plated at differentiating condi...

Kv4 (Shal) potassium channels are responsible for the transient outward K(+) currents in mammalian hearts and central nervous systems. Heteropoda toxin 2 (HpTx2) is an inhibitor cysteine knot peptide toxin specific for Kv4 channels that inhibits gating of Kv4.3 in the voltage-dependent manner typical for this type of toxin. HpTx2 interacts with four independent binding sites containing two cons...