Pedophilia is defined as the permanent attraction or sexual interest towards prepubescent children. However, prior studies suggested that pedophilia is not necessary and moreover not sufficient to solely account for committing sexual offenses against children, but constitutes a significant risk factor (Seto, 2008). Up to now, there is a dearth of studies concerning the neural basis of a) pedoph...

The inhibition of excitatory (pyramidal) neurons directly dampens their activity resulting in a suppression of neural network output. The inhibition of inhibitory cells is more complex. Inhibitory drive is known to gate neural network synchrony, but there is also a widely held view that it may augment excitability by reducing inhibitory cell activity, a process termed disinhibition. Surprisingl...

The current study, which focuses on the benign effects of disinhibition, was designed as a continuation of an earlier study conducted on the toxic effects of online disinhibition (LapidotLefler & Barak, 2012). Using a factorial design, the study examined the effects of three online situational factors—anonymity, invisibility, and lack of eye contact—on inducing self-disclosure and prosocial beh...

Our aim in the present study was to investigate the psychological mechanisms that underlie the disinhibiting effects of alcohol cues in social drinkers by contrasting motor and oculomotor inhibition after exposure to alcohol-related, emotional, and neutral pictures. We conducted 2 studies in which social drinkers completed modified stop-signal (laboratory) and antisaccade (online) tasks in whic...

OBJECTIVE To relate changes in fractional anisotropy associated with behavioral variant frontotemporal dementia to measures of apathy and disinhibition. BACKGROUND Apathy and disinhibition are the 2 most common behavioral features of behavioral variant frontotemporal dementia, and these symptoms are associated with accelerated patient decline and caregiver stress. However, little is known abo...

Two online surveys were conducted to assess the relationship between trait disinhibition, impulsivity, mindfulness and adverse psychological symptoms. In study 1 adult females (n=196; mean age=21 yrs) completed the Three-Factor Eating Questionnaire (TEFQ-R21), the Hospital Anxiety and Depression Scale and a measure of dispositional mindfulness. In study 2 adult females (n=190; mean age=26 yrs) ...

Excitation-inhibition balance (E/I balance) is a fundamental property of cortical microcircuitry. Disruption of E/I balance in prefrontal cortex is hypothesized to underlie cognitive deficits observed in neuropsychiatric illnesses such as schizophrenia. To elucidate the link between these phenomena, we incorporated synaptic disinhibition, via N-methyl-D-aspartate receptor perturbation on intern...

BACKGROUND A number of countries in sub-Saharan Africa are preparing for HIV vaccine efficacy trials. Social and behavioural factors related to HIV transmission require examination in each setting where these trials are considered. As part of this, several countries have also recently begun preparatory research investigating relevant social and behavioural issues. There is a need for a review o...

Abstract The triarchic model of psychopathy conceptualizes variants this clinical condition as expressions three distinct biobehavioral dispositions, termed boldness, meanness, and disinhibition. As a trait-oriented model, the situates within broader nomological network personality psychopathology, has proven useful for characterizing how relates to variables in these domains well biological be...