OBJECTIVES This study aimed to develop a scoring system to predict the survival time of patients with bone metastases after radiation therapy (RT). The scoring system can guide physicians to a better selection of appropriate treatment regimens. MATERIALS AND METHODS The medical records of 125 patients with bone metastases treated with RT between January 2007 and September 2010 were reviewed r...

BACKGROUND Two genome scans for susceptibility loci for type 1 diabetes using large collections of families have recently been reported. Apart from strong linkage in both studies of the HLA region on chromosome 6p, clear consistent evidence for linkage was not observed at any other loci. One possible explanation for this is a high degree of locus heterogeneity in type 1 diabetes, and we hypothe...

INTRODUCTION Reducing high-risk behaviours (i.e. multiple partnership, condomless anal/vaginal sex, alcohol use before sex, illicit drug use) after HIV diagnosis is critical for curtailing HIV transmission. We designed an intervention to explore peer- counselling in reducing high-risk behaviours among newly diagnosed HIV-positive Chinese men who have sex with men (MSM). METHODS We randomized ...

Bipolar disorder (BD) is a psychiatric associated with brain and neurodevelopmental alterations. As in other disorders, patients BD present minor Physical Anomalies (MPAs) higher frequency than healthy subjects. MPAs are subtle signs of developmental deviation that appear body regions share the ectodermal origin likely triggered by same insults altering early development mental disorders. thus ...

OBJECTIVE To do clinical, hormonal and chromosomal analysis in undervirilized male / XY disorder of sex development and to make presumptive etiological diagnosis according to the new Disorder of Sex Development (DSD) classification system. STUDY DESIGN Case series. PLACE AND DURATION OF STUDY Endocrine Unit at National Institute of Child Health, Karachi, Pakistan, from January 2007 to Decem...

OBJECTIVE Alpha-inhibin and calretinin have been traditionally used as immunomarkers for sex cord stromal tumors. However, the variation in their immunoreactivity and their lack of specificity for sex cord stromal tumor makes the search for a more sensitive and specific immunohistochemical marker essential in routine diagnosis of sex cord stromal tumor. This study was conducted to correlate the...

740 DR. GRUMBACH: Barr and associates have demonstrated that in the human the majority of somatic cells of females contain a conspicuous, heterochromatic mass of chromatin in the resting nuclei. Their discovery of a sex-difference in intermitotic nuclei of a number of vertebrate species, including man, has provided a relatively simple method for assessing the sex-chromosome constitution. This c...