The recent discovery and structure elucidation of approximately 100 new sesquiterpene lactones during a systematic study of Artemisia and other genera of the family of Compositae in our laboratory (16) have provided the opportunity for further investigations on the potential of these sesquiterpene lactones as new therapeutic agents. Much of the earlier study on sesquiterpene lactones for medici...

Column chromatographic separation of a MeOH extract of the aerial parts of Saussurea triangulata led to the isolation of a new sesquiterpene glycoside 6, together with three quinic acid derivatives, two phenolics, two sesquiterpene glycosides and two flavonoids. The new compound 6 was identified as amarantholidol A glycoside by spectroscopic and chemical methods.

* corresponding author, e-mail : [email protected] Abstract: A sesquiterpene lactone 1 Lacinin and a sesquiterpene lactone glucoside 2 Laciniside, were isolated from the flowers of Pulicaria laciniata. Their structures were elucidated by extensive spectroscopic methods including 1D-( 1 H and 13 C) and 2D-NMR experiments, (CHcorr, HMBC, 1 H1 H COSY and NOESY) as well as high resolution E...

A new sesquiterpene aminoquinone, 5-epi-smenospongorine, together with nine known sesquiterpene quinone/phenols, was isolated as differentiation-inducing substances to K562 cells into erythroblast from the marine sponge Dactylospongia elegans. The structure-activity relationship study of these compounds clarified that the quinone skeleton is indispensable and the amino group plays an important ...

The main structural unit of the title compoud, C(21)H(18)O(6), is a fused three-ring group consisting of coumarin and tetra-hydro-pyrane ring systems. Two C atoms of the tetra-hydro-pyran ring are displaced by 0.295 (3) and -0.360 (2) Å from the mean plane of coumarin ring. The dihedral angle between the phenyl and coumarin rings is 73.94 (3)°. Inter-molecular O-H⋯O hydrogen bonds are present i...

the synthesis of functionalized 2-oxo-2h-coumarin derivatives has been studied by a one-pot reaction of o-hydroxybenzaldehyde, ethyl 2-bromoacetate and triphenylphosphine in the presence of catalytic amount of triethyl amine in etoac, water or under solvent free conditions. we have found the best results obtained under solvent free condition.

Previous investigations have shown that CY4-labeled transcinnamic acid is rapidly converted to o-coumaric acid P-glucoside by shoots of Melilotus alba (white sweet clover) (1) and Hierochlod odorata (sweet grass) (2). This glucoside is then converted to coumarin (l-3), possibly by way of trans-cis isomerization of the glucoside to coumarinic acid P-glucoside. The small amount of radioactivity f...

ABSTRACT. Among oxygen-containing heterocyclic compounds such as coumarin and azacoumarin derivatives, the scaffold has become an important construction motif for developing new drugs. Coumarin its derivatives possess many types of biological activities have been reported to show significant cytotoxic activity. N-(6,8-disubstituted coumarin-3-yl)benzamides (8a-c) namely (3-N-(benzoyl) aminocoum...

Clionaterpene (1), a new cadinene sesquiterpene, along with six known compounds 2–7 were isolated from the marine sponge Cliona sp. The structure of 1 absolute configuration was determined by spectroscopic data (UV, IR, MS, and NMR) quantum chemical calculation. Compound first sesquiterpene metabolite this genus. In addition, cytotoxic antibacterial activities these evaluated. However, none the...