The importance of immunoglobulin E (IgE) in atopic disorders such as asthma, allergic rhinitis, food allergies, and atopic dermatitis is well established. Elevation of total serum IgE is typically found in many atopic patients, and in predisposed individuals, allergen-specific IgE is produced. The availability of humanized monoclonal antibodies against IgE has provided a new therapeutic option ...

Pulmonary hypertension (PH) is a severe cardiopulmonary disease characterized by pulmonary vascular remodeling. Immunoglobulin E (IgE) known to participate in aortic remodeling, but whether IgE mediates unknown. In the present study, we found serum elevation arterial (PAH) patients, hypoxia-induced PH mice and monocrotaline-induced rats. Neutralizing with an anti-IgE antibody was effective prev...

PURPOSE To detect risk factors that may be related to chalazia in children in southwest China. DESIGN Prospective case-control study. METHODS The case group, 88 children with chalazia, was divided into 2 subgroups. One had 48 children 6 months to 6 years of age (defined as young children), and the other had 40 children 7 to 12 years of age (defined as older children). The control group cons...

OBJECTIVE Irritant gases and aerosols contaminating the air of indoor swimming pools can affect the lung epithelium and increase asthma risk in children. We evaluated the impact of infant swimming practice on allergic status and respiratory health later in childhood. METHODS Clara cell protein, surfactant-associated protein D, and total and aeroallergen-specific immunoglobulin E were measured...

background: idiopathic anterior uveitis is an anterior segment inflammation in which a detailed medical history, general and ocular physical examination is not associated with any defined clinical syndrome. alterations in immune system parameters have been reported in patients with idiopathic posterior uveitis; however no data on the role of immune system in idiopathic anterior uveitis has yet ...