BACKGROUND AND OBJECTIVES Serum creatinine concentrations tend to be higher in black than white individuals and people of other races or ethnicities. These differences have been assumed to be largely related to race-related differences in body composition, especially muscle mass. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS In a diverse population of hemodialysis patients, we compared mean s...

Clinicians have used serum creatinine in diagnostic testing for acute kidney injury for decades, despite its imperfect sensitivity and specificity. Novel tubular injury biomarkers may revolutionize the diagnosis of acute kidney injury; however, even if a novel tubular injury biomarker is 100% sensitive and 100% specific, it may appear inaccurate when using serum creatinine as the gold standard....

BACKGROUND A low ankle-brachial index (ABI) predicts risk of cardiovascular death, myocardial infarction, peripheral arterial disease events, and stroke. However, it is unknown whether a low ABI also predicts a decline in renal function. METHODS We examined the association between ABI and change in serum creatinine level over time among 13 655 participants in the Atherosclerosis Risk in Commu...

BACKGROUND The epidemiology of kidney disease is not extensively described in dogs. HYPOTHESIS/OBJECTIVES To better understand the prevalence of elevated serum creatinine concentration in dogs. ANIMALS Client-owned dogs. METHODS A retrospective, observational cross-sectional study design was used. We made a dataset of 115,631 hospital visits of all dogs presenting from October 2010 to Oct...

  Objective(s): Because of the high total phenolic contents of Feijoa sellowiana , its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice.   Materials and Methods: Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP)...

We evaluated and compared three analytical procedures for measuring creatinine by testing pooled sera and sera from individual human subjects. In two of the methods, an enzymic and a conventional colorimetric procedure, creatinine was separated from serum proteins with tungstic acid and detected at 520 nm after reaction with alkaline picrate (Jaff#{233} reagent). The amount of enzymaticaIly act...

Serum creatinine is commonly used as a marker of renal function, but increases in serum creatininemight not represent changes in glomerular filtration rate (GFR). INCB039110 (2-(3-(4-(7H-pyrrolo[2,3-day]pyrimidin4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl) piperidin-4-yl)azetidin-3-yl)acetonitrile) is an inhibitor of the Janus kinases (JAKs) with selectivity for JAK1....