Reactive oxygen species are implicated as mediators of tissue damage in ischemic and toxic acute renal failure. Whereas many agents can inhibit renal ischemic injury, only hepatocyte growth factor, melatonin, N-acetylcysteine, and DMSO inhibit injury after mercuric chloride administration. Although it has been suggested that DMSO may chelate the mercuric ion, more recent studies suggest that it...

Depression of the melting point of liver tissue rapidly frozen by liquid nitrogen during life provides a means by which the molecular concentration within liver cells may be compared with that of solutions of sodium chloride or of blood or of blood serum. The rising temperature of frozen blood of guinea pig under the conditions of these experiments is retarded when melting occurs, pursues when ...

It has long been known that during the course of lobar pneumonia alterations in the chloride distribution in the blood and urine occur. During the stage of active infection there is a retention of chloride in the body as manifested by a decreased chloride elimination, whereas the blood in this period shows a hypochloremia. The present study was designed to follow the changes in the concentratio...

Pseudohyponatremia is caused by an increased serum protein or lipid concentration producing a "space-occupying lesion" in serum water. Its presence and magnitude must be assessed in hyponatremic patients with, for example, paraproteinemia or hyperlipemic diabetic coma. In the absence of a direct-reading ion-selective electrode system, a method for measuring the water content of serum is require...

Response to Effect of Serum Chloride on Mortality in Hypertensive Patients We thank Kawada for the comments1 on our article.2 We recognize the importance of lipids in outcomes. We had only baseline total cholesterol available in a subset of patients, and it was not associated with either all-cause or cardiovascular mortality. Furthermore, incorporation of baseline total cholesterol in the model...

PRESENTATION Three patients developed acute respiratory failure during treatment of diabetic ketoacidosis (DKA) diagnosed by the combination of hyperglycemia, anion gap metabolic acidosis, and presence of ketone bodies in serum. All three required tracheal intubation and mechanical ventilation. Table 1 shows pertinent laboratory values at admission and immediately before tracheal intubation. Se...

The recent trials of gentisic acid as a therapeutic agent (1, 2)’ stimulated our interest in the development of methods for the determination of gentisic acid in serum. Meyer and Ragan (1) referred to a method which is suitable for the analysis of gentisic acid in urine. No details were given. Although they were able to detect 5 y of hydroquinone per ml. in urine (l), they did not find detectab...

Abstract Background Laryngoscopy and endotracheal intubation may be associated with adverse events as hypertension, tachycardia, increased serum concentrations of catecholamines. These are serious in patients cardiac diseases or hypertension. This work was designed to assess the effects single dose dexmedetomidine on hemodynamic response controlled hypertensive patients. Methods Seventy were ra...

The serum or plasma biochemical profile is essential in the diagnosis and monitoring of systemic disease in veterinary medicine, but current reference intervals typically take no account of breed-specific differences. Breed-specific hematological phenotypes have been documented in the domestic dog, but little has been published on serum biochemical phenotypes in this species. Serum biochemical ...