background: immune reactions have been reported to be involved in the destruction of retinal ganglion cells (rgcs) in glaucoma. objective: to investigate the role of major histocompatibility complex class i-related chain a and b (mica and micb) molecules in the pathogenesis of glaucoma. methods: aqueous humor and serum samples from 15 glaucoma patients and 45 patients with cataract, undergoing ...

BACKGROUND The aim was to evaluate the efficacy of periocular intense pulsed light therapy combined with meibomian gland expression for chronic dry eye due to moderate to advanced meibomian gland dysfunction. METHODS This single-institution, open-label prospective study involved 26 participants who received bilateral treatments using a proprietary intense pulsed light device (E > Eye, E-Swin,...

OBJECTIVE To establish a protocol for the use of autologous serum in the ophthalmic practice. METHODS Personal experience and a literature review. RESULTS The use of autologous serum, in eye drop form, has been reported as a new treatment for several ocular surfaces diseases. These products have biomechanical and biochemical properties similar to normal tears. They contain components such a...

Allogeneic hematopoietic stem cell transplantation (HSCT) is a well-established therapeutic option for a range of inherited and acquired hematological disorders. However, graft-versus-host disease (GVHD) remains the leading cause of non-relapse mortality in allogeneic HSCT recipients. Ocular involvement occurs in up to 80% of chronic GVHD patients. In our cases, the diagnosis of vitamin A defic...

BACKGROUND Acute gastroenteritis (AGE) remains a common cause of clinic visits and hospitalizations in the United States, but the etiology is rarely determined. METHODS We performed a prospective, multicenter emergency department-based study of adults with AGE. Subjects were interviewed on presentation and 3-4 weeks later. Serum samples, rectal swab specimens, and/or whole stool specimens wer...

Background: Rheumatoid Arthritis patients are evaluated during treatment for various inflammatory factors such as C-reactive protein, Erythrocyte Sedimentation Rate, and Disease Activity Score, and other immune system-related factors. In the follow-up of patients with rheumatoid arthritis, hematologic factors associated with the immune system especially Platelet to Lymphocyte Ratio and Neutroph...

Background: Tolmetin (Tol) is a pyrrole acetic acid derivative that acts as a highly effective topical anti-inflammatory agent. Topical administration of Tol is effective for the management of ocular inflammations.The aim of this study was to formulate and improve a topical ophthalmic delivery system of Tol. Materials and methods: In the present study, ocular inserts of Tol were prepared using ...

Intravitreally administered lampalizumab is an investigational complement inhibitor directed against complement factor D (CFD) for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration. We sought to develop an integrated ocular and systemic pharmacokinetic/pharmacodynamic model for lampalizumab in patients with GA using the data from the clinical phase I and II ...

The aim of this study was to determine the prevalence and type of ophthalmic diseases among horse populations in the suburbian riding clubs of Tehran. Ophthalmologic examinations were performed in 901 horses and ocular lesions were diagnosed in 40 (4.4%) animals. In the 54 eyes of these horses that had ocular defects, 103 ocular abnormalities were detected. Of those horses affected, 65% showed ...

Background and aims: Toxoplasmosis is a parasitic disease which may cause some laboratory symptoms in infected individuals. One of the main ways of transmition this organism is placenta to fetus pathway. If this transmission occurs in the 3th month of pregnancy, the abortion, central nerve system and ocular disorder will happen. Because of this issue, the precise technique for detection of Toxo...