Serum alanine aminotransferase, aspartate aminotransferase and gamma-glutamyltransferase activities were monitored in psychiatric patients receiving normal doses of phenothiazine neuroleptics over a 30-day period. The first two enzymes showed slight initial increases and a subsequent return to normal, while the third showed a slight increase. In rats, dosage levels exceeding those used in human...

OBJECTIVES To determine the prevalence and determinants of acute pancreatitis in patients with acute brucellosis. METHODS Adult patients with brucellosis were retrospectively recruited. Brucellosis and acute pancreatitis were diagnosed according to standard criteria. Laboratory analyses included Wright agglutination titre, serum biochemical parameters and blood count. RESULTS Patients with ...

Enzymes are produced intracellularly, and released into the plasma and body fluids, where their activities can be measured by their abilities to accelerate the particular chemical reactions they catalyze. But different serum enzymes are raised when different tissues are damaged. So serum enzyme determination can be used both to detect cellular damage and to suggest its location in situ. Some of...

Effects of serum and protein on assays measuring aspartate aminotransferase (L-aspartate: 2-oxoglutarate aminotransferase, EC 2.6.1.1) were examined. Increasing amounts of normal human serum or human serum albumin in samples with fixed amounts of purified enzyme decrease absorbance values and thus distort the results obtained in an assay in which diazonium-salt chromogenic reagent is used. Seru...

The objective of this study was to determine the effect of age on the response of enzyme activities in blood serum of growing broiler chickens. The research was conducted on Ross 308 chickens. Blood serum samples were collected three times at 14, 21 and 42 days of age. Significant effects of age were found for both aspartate aminotransferase (AST) and lactate dehydrogenase (LDH).There were no s...

Results Maternal mortality rate was 14% and perinatal death occurred in 24 of 81 fetuses and newborn (30%). The most common cause of maternal complications was disseminated intravascular coagulation in 22 patients (29%), acute renal failure in 19 patients (25%), and postpartum hemorrhage in 16 patients (21%). Compared with surviving women, non-surviving women had higher mean values for internat...

Liver function and its correlation with bilirubin and hepatic enzymes were evaluated in 30 male chronic asymptomatic or oligosymptomatic alcoholics admitted into the psychiatric hospital for detoxification and treatment of alcoholism. Hypoalbuminemia, lowered prothrombin activity, hypotransferrinemia and hypofibrinogenemia were detected in 32%, 32%, 28%, and 24% of patients, respectively. Trans...

Guava leaves have been used to treat cough and pulmonary diseases; they have also served as anti inflammatory and haemostatic agent in china. This work is therefore aimed at investigating the effects of guava leaf extract on the liver enzymes of adult wistar rats. Twenty apparently healthy wistar rats were used for this study. They were allocated into four groups (A, B, C & D) of five animals e...

Conditions for accurate measurement of catalytic activity of aspartate aminotransferase and alanine aminotransferase in human serum have been reinvestigated. The basic variables (kind of buffer, buffer concentration, pH, ion effects, and the influence of pyridoxal-5-phosphate) can now be considered optimized. On this basis, the kinetic parameters of both aminotransferases were determined, i.e.,...

PURPOSE The association between liver enzymes and death from external causes has not been examined. We investigated the association between serum aminotransferase levels and external-cause mortality in a large prospective cohort study. MATERIALS AND METHODS A total of 142,322 subjects of 35-59 years of age who completed baseline examinations in 1990 and 1992 were enrolled. Mortalities were id...