نتایج جستجو برای: sertoli

تعداد نتایج: 4120  

Journal: :Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia 2013
Maristela T Pimenta Catarina S Porto Maria F M Lazari

Spermatogenesis is controlled by FSH, testosterone and paracrine factors produced by Sertoli cells. The knockout of relaxin decreases sperm maturation in mice. Studies from our laboratory have shown that relaxin and its receptor RXFP1 are expressed in rat Sertoli cells, and exogenous relaxin stimulates Sertoli cell proliferation. Relaxin receptors are also detected in the rat germ cells at spec...

Journal: :Development 1991
S J Palmer P S Burgoyne

The testes of fetal, prepuberal and adult XX----XY chimaeras were examined using in situ hybridisation to identify the beta-globin transgenic marker contained in one component of each chimaera. This enabled the proportion of XX and XY cells contributing to the major cell lineages of the testis to be estimated from sectioned and air-dried material. A few XX Sertoli cells were found in all three ...

2014
Xiaohua Jiang Huan Zhang Shi Yin Yuanwei Zhang Weimei Yang Wei Zheng Liu Wang Zheng Wang Ihtisham Bukhari Howard J. Cooke Furhan Iqbal Qinghua Shi

Ztbt20 is a POK family transcription factor and primarily functions through its conserved C2H2 Krüppel type zinc finger and BTB/POZ domains. The present study was designed to define the function of the Zbtb20, in vivo, during mouse spermatogenesis. Immunohistochemical studies revealed that ZBTB20 protein was localized specifically in the nuclei of Sertoli cells in seminiferous tubules. To inves...

Journal: :Folia histochemica et cytobiologica 2007
Renata Walczak-Jedrzejowska Jolanta Slowikowska-Hilczer Katarzyna Marchlewsk Elzbieta Oszukowska Krzysztof Kula

UNLABELLED During establishment of spermatogenesis at the prepubertal age, an early germ cells apoptotic wave occurs likely aimed to remove abnormal germ cells and to maintain a proper cell number ratio between maturating germ cells and Sertoli cells. Here we assessed Sertoli and germ cell apoptosis in relation to morphological parameters of Sertoli cell maturation in neonatal rats under the in...

2013
Kuo-Chung Lan Yen-Ta Chen Chawnshang Chang Yung-Chiao Chang Hsin-Jung Lin Ko-En Huang Hong-Yo Kang

BACKGROUND Testosterone provokes Sertoli cell maturation and represses AMH production. In adult patients with Sertoli-cells-only syndrome (SCOS) and androgen insensitivity syndrome (AIS), high level of AMH expression is detected in Sertoli cells due to defect of androgen/AR signaling. OBJECTIVE We postulated that up-regulation of SOX9 due to impairment of androgen/AR signaling in Sertoli cell...

Journal: :The Journal of Cell Biology 1999
Antonella Tripiciano Carmelina Peluso Anna Rita Morena Fioretta Palombi Mario Stefanini Elio Ziparo Masashi Yanagisawa Antonio Filippini

The potent smooth muscle agonist endothelin-1 (ET-1) is involved in the local control of seminiferous tubule contractility, which results in the forward propulsion of tubular fluid and spermatozoa, through its action on peritubular myoid cells. ET-1, known to be produced in the seminiferous epithelium by Sertoli cells, is derived from the inactive intermediate big endothelin-1 (big ET-1) throug...

Fatemeh Mansouri Karim Nayernia Mahdi Dianatpour Mohammad Hossein Modarressi* Mohammad Miryounesi

  Objective(s): Sertoli cells support in vivo germ cell production; but, its exact mechanism has not been well understood. The present study was designed to analyze the effect of Sertoli cells in differentiation of mouse embryonic stem cells (mESCs) to germ cells.   Materials and Methods: A fusion construct composed of a Stra8 gene promoter and the coding region of enhanced green fluorescence p...

A Mohseni Meybodi F Sangsefidi M Sabbaghian, MA Sadighi Gilani, P Mokhtari

Background Sertoli cells located in seminiferous tubular basement membrane and surrounds different types of germ cell and they were only somatic cell type that directly contacts germ cells. These cells have Several role like support activities, nutrition of germ cells.During spermatogenesis, expression of SOX3 is necessary for differentiation of spermatogonia A. SOX3 is a transcription factor, ...

Journal: :Histology and histopathology 1991
M Rodríguez Barbudo A Méndez Sánchez A Blanco Rodríguez

The morphological alterations caused by anabolic steroids (oestradiol and trenbolone acetate) on the Sertoli cells of testicles in animals for human consumption (lambs and calves) were studied. The morphopathological study of the treated lambs revealed delayed development of the seminiferous tubules, which was marked by signs of immaturity and even degeneration of Sertoli cells. The main morpho...

2012
Otávio Brilhante Fatima K Okada Estela Sasso-Cerri Taiza Stumpp Sandra M Miraglia

BACKGROUND Doxorubicin is a potent chemotherapeutic drug used against a variety of cancers. It acts through interaction with polymerases and topoisomerase II and free radical production. Doxorubicin activity is not specific to cancer cells and can also damage healthy cells, especially those undergoing rapid proliferation, such as spermatogonia. In previous studies our group showed that etoposid...

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