Recent studies have powerfully demonstrated that women with depression, whether treated with SSRIs or skip treatment, report double risk of cardiovascular malformations. Yet, physicians and epidemiologists continue to terrify women who are at serious life threatening risks if not treated pharmacologically, with non evidence-based information. This paper calls for immediate stop of such practice.

[This corrects the article DOI: 10.1371/journal.pone.0108048.].

Styrylquinoline derivatives are demonstrated to be HIV-1 integrase inhibitors. On the basis of our previous CoMFA analysis of a series of styrylquinoline derivatives, N-[(2-substituted-styryl)-5-chloro-8-hydroxyquinolin-7-yl]-benzenesulfonamide derivatives were designed and synthesized,and their possible HIV IN inhibitory activity was evaluated.

In the course of investigations, aiming at the development of enzyme inhibitors to be used as “enzyme reagents” in complex biochemical systems (l-6), special attention was paid to analogues of physiological enzyme substrates which occupy key positions in branching points of metabolic pathways. The present work deals with the chemical and enzyme-inhibitory properties of a hitherto unknown analog...

The field of erectile dysfunction continues to evolve. Updated AUA Erectile Dysfunction Guidelines and the second Princeton Consensus Panel Guidelines, as well as updates regarding the oral PDE-5 inhibitors, are the focus of this article.

We review the cardiovascular effects of newer antidepressants. Although further studies are warranted, the safety of the selective serotonin reuptake inhibitors and the serotonin norepinephrine reuptake inhibitors on patients with comorbid cardiac conditions is impressive. Newer antidepressants should be considered as first-line agents for the treatment of depression in patients with and withou...

Absolute pitch, the ability to identify or produce the pitch of a sound without a reference point, has a critical period, i.e., it can only be acquired early in life. However, research has shown that histone-deacetylase inhibitors (HDAC inhibitors) enable adult mice to establish perceptual preferences that are otherwise impossible to acquire after youth. In humans, we found that adult men who t...